化脓性汗腺炎中的肥大细胞：一项临床病理研究。

Mast cells in hidradenitis suppurativa: a clinicopathological study.

机构信息

Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.

Health Sciences Faculty, University of Copenhagen, Copenhagen, Denmark.

出版信息

Arch Dermatol Res. 2019 May;311(4):331-335. doi: 10.1007/s00403-019-01910-3. Epub 2019 Mar 15.

DOI:10.1007/s00403-019-01910-3

PMID:30877368

Abstract

Mast cells (MC) have been observed in hidradenitis suppurativa (HS) lesions. Their potential role in the pathogenesis of HS is unknown. The aim of this study was to assess the number and distribution MC in HS lesions, and its association with disease and itch severity. We studied biopsies from HS-lesions and perilesional skin from 34 HS patients. The samples were stained with CD117 and toluidine blue, and the number of MC determined semi-quantitatively (40 × magnification). The distribution of MC was also noted. The clinical features of the disease were extracted from patients' case records and a questionnaire-based database. MC were present to a greater degree in HS-lesions than in perilesional skin (P = 0.004). Disease severity (Sartorius score) was correlated to with MC count and itch when adjusted for sex and age (P = 0.042). Duration of the disease could not been significantly correlated with MC count. A positive correlation between MC count and HS activity was detected, suggesting a potential link between MC and HS.

摘要

肥大细胞（MC）已在化脓性汗腺炎（HS）病变中被观察到。它们在 HS 发病机制中的潜在作用尚不清楚。本研究旨在评估 HS 病变中 MC 的数量和分布及其与疾病和瘙痒严重程度的关系。我们研究了 34 例 HS 患者的 HS 病变和病变周围皮肤的活检。用 CD117 和甲苯胺蓝对样本进行染色，并通过半定量（40×放大倍数）确定 MC 的数量。还注意到 MC 的分布。从患者的病历和基于问卷的数据库中提取疾病的临床特征。与病变周围皮肤相比，HS 病变中 MC 的存在程度更高（P=0.004）。当调整性别和年龄时，疾病严重程度（Sartorius 评分）与 MC 计数和瘙痒相关（P=0.042）。疾病持续时间不能与 MC 计数显著相关。检测到 MC 计数与 HS 活性之间存在正相关，这表明 MC 与 HS 之间可能存在联系。