抗惊厥药对豚鼠海马切片中青霉素诱发的爆发活动的影响。

Effects of anticonvulsants on penicillin-induced bursting in guinea pig hippocampal slices.

作者信息

Schneiderman J H, Evans J C

出版信息

Epilepsia. 1986 Jul-Aug;27(4):347-53. doi: 10.1111/j.1528-1157.1986.tb03552.x.

DOI:10.1111/j.1528-1157.1986.tb03552.x

Abstract

The effects of gamma-aminobutyric acid (GABA) and six anticonvulsants on penicillin-induced bursting were compared in guinea pig hippocampal slices. GABA, phenobarbital, pentobarbital, phenytoin, and diazepam slowed and eventually blocked spontaneous bursts. Low-intensity stimulation at concentrations that blocked spontaneous activity still evoked synchronous all-or-none burst responses, although the threshold increased and the bursts were briefer. Sodium valproate had similar effects, but very high concentrations (approximately 10 mM) were required. Ethosuximide paradoxically increased spontaneous burst rate. This model appears to be differentially susceptible to the actions of GABA and the anticonvulsants commonly used to treat tonic-clonic and partial seizures but not to the antiabsence drugs.

摘要

在豚鼠海马切片中比较了γ-氨基丁酸（GABA）和六种抗惊厥药对青霉素诱发的爆发性放电的影响。GABA、苯巴比妥、戊巴比妥、苯妥英和地西泮减缓并最终阻断了自发性爆发。在阻断自发性活动的浓度下进行低强度刺激仍能诱发同步的全或无爆发反应，尽管阈值升高且爆发持续时间更短。丙戊酸钠有类似作用，但需要非常高的浓度（约10 mM）。乙琥胺反而增加了自发性爆发率。该模型似乎对GABA和常用于治疗强直阵挛性发作及部分性发作的抗惊厥药的作用敏感性不同，但对抗失神发作药物不敏感。