Department of Radiology, Hôpital Ambroise Paré, Boulevard Président Kennedy 2, 7000, Mons, Belgium.
Department of Pneumology, Hôpital Erasme, Route de Lennik 808, 1070, Brussels, Belgium.
Eur Radiol. 2019 Oct;29(10):5307-5313. doi: 10.1007/s00330-019-06055-5. Epub 2019 Mar 15.
To determine the variabilities of dose-area-products (DAP) of frequent X-ray examinations collected for comparison with diagnostic reference levels (DRLs).
DAP values of chest, abdomen, and lumbar spine examinations obtained on devices from two manufacturers were collected in three centers over 1 to 2 years. The variability of the average DAP results defined as the 95% confidence interval in percentage of their median value was calculated for increasing sample sizes, each examination and center. We computed the sample sizes yielding variabilities lower or equal to 25% and 10%. The effect of narrowing patient selection based on body weight was also investigated (ranges of 67-73 Kg, or 60-80 Kg).
DAP variabilities ranged from 75 to 170% of the median value when collecting small samples (10 to 20 DAP). To reduce this variability, larger samples are needed, collected over up to 2 years, regardless of the examination and center. A variability ≤ 10% could only be reached for chest X-rays, requiring up to 800 data. For the abdomen and lumbar spine, the lowest achievable variability was 25%, regardless of the body weight selection, requiring up to 400 data.
Variabilities in DAP collected through small samples of ten data as recommended by authorities are very high, but can be reduced down to 25% (abdomen and lumbar spine) or even 10% (chest) through a substantial increase in sample sizes. Our findings could assist radiologists and regulatory authorities in estimating the reliability of the data obtained when performing X-ray dose surveys.
• Low but reasonable variabilities cannot be reached with samples sized as recommended by regulatory authorities. Higher numbers of DAP values are required to reduce the variability. • Variabilities of 10% for the chest and 25% for abdomen and lumbar spine examinations are achievable, provided large samples of data are collected over 1 year. • Our results could help radiologists and authorities interpret X-rays dose surveys.
确定频繁 X 射线检查的剂量面积乘积(DAP)的可变性,以便与诊断参考水平(DRL)进行比较。
在两个制造商的设备上,在三个中心收集了为期 1 至 2 年的胸部、腹部和腰椎检查的 DAP 值。对于每个检查和中心,计算了随着样本量增加,以中位数为中心的 95%置信区间定义的平均 DAP 结果的变异性。我们计算了产生变异性低于或等于 25%和 10%的样本量。还研究了基于体重缩小患者选择的效果(67-73 公斤或 60-80 公斤的范围)。
当收集小样本(10 至 20 个 DAP)时,DAP 变异性范围为中位数的 75%至 170%。为了降低这种变异性,需要更大的样本量,最长可达 2 年,无论检查和中心如何。仅当胸部 X 射线的样本量达到 800 个时,才能达到≤10%的可变性。对于腹部和腰椎,无论体重选择如何,最低可达到 25%的可变性,需要 400 个数据。
当局推荐的十项数据小样本中收集的 DAP 变异性非常高,但通过大量增加样本量,可将变异性降低至 25%(腹部和腰椎)甚至 10%(胸部)。我们的研究结果可以帮助放射科医生和监管机构估计在进行 X 射线剂量调查时获得数据的可靠性。
按照监管机构推荐的样本量,无法达到较低但合理的变异性。需要更多的 DAP 值来降低变异性。
胸部检查的 10%,腹部和腰椎检查的 25%的变异性是可以达到的,前提是在 1 年内收集大量数据。
我们的结果可以帮助放射科医生和当局解释 X 射线剂量调查。