Bauermeister José A, Golinkoff Jesse M, Carballo-Diéguez Alex, Giguere Rebecca, López Daniela, Hoesley Craig J, Chen Beatrice A, Anderson Peter, Dezzutti Charlene S, Strizki Julie, Sprinkle Carol, Heard Faye, Hall Wayne, Jacobson Cindy, Berthiaume Jennifer, Mayo Ashley, Richardson Barbra A, Piper Jeanna
School of Nursing, University of Pennsylvania, 418 Curie Blvd., Suite 222L, Philadelphia, PA, 19104, USA.
Department of Psychiatry, Columbia University, New York, USA.
AIDS Behav. 2020 Feb;24(2):607-616. doi: 10.1007/s10461-019-02457-0.
Intravaginal rings (IVR) containing antiretroviral drugs are a promising method for HIV prevention. We triangulated quantitative and qualitative assessments to evaluate the acceptability of four IVRs used continuously for 28 days as part of a Phase I trial (N = 48 HIV-negative women; ages 18-45). Adherence was high throughout the trial, yet 30% of participants reported involuntary IVR expulsions followed by re-insertion. Most participants (93.6%) felt comfortable with the IVR being inside their body. Participants reported liking the IVR more (36.2%) or the same amount (55.3%) since starting the study. When given the option of choosing between the IVR and/or a male condom for HIV-prevention, most reported preferring the IVR (n = 29, 63.0%), and over a quarter of the sample reported liking them equally (n = 12, 26.1%). We observed no differences in IVR acceptability across the study arms. High adherence and acceptability underscores the promise of an IVR as a female-controlled, sustained mechanism for HIV prevention.
含有抗逆转录病毒药物的阴道环（IVR）是一种很有前景的HIV预防方法。作为一项I期试验的一部分（N = 48名HIV阴性女性；年龄18 - 45岁），我们采用定量和定性评估相结合的方法，来评估连续使用28天的四种阴道环的可接受性。在整个试验过程中依从性很高，但30%的参与者报告有阴道环非自愿排出并随后重新插入的情况。大多数参与者（93.6%）对阴道环在体内的情况感觉舒适。自开始研究以来，更多参与者（36.2%）或同等比例（55.3%）的参与者表示更喜欢阴道环。当被问及在阴道环和/或男用避孕套之间选择用于HIV预防时，大多数人报告更喜欢阴道环（n = 29，63.0%），超过四分之一的样本报告同样喜欢两者（n = 12，26.1%）。我们观察到各研究组在阴道环可接受性方面没有差异。高依从性和可接受性凸显了阴道环作为一种女性可控的、持续的HIV预防机制的前景。
