A、B、C、W、X和Y群脑膜炎球菌血清杀菌抗体检测
Meningococcal Serogroup A, B, C, W, X, and Y Serum Bactericidal Antibody Assays.
作者信息
Lucidarme Jay, Louth Jennifer, Townsend-Payne Kelly, Borrow Ray
机构信息
Meningococcal Reference Unit, National Infection Service, Public Health England, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Manchester, UK.
Vaccine Evaluation Unit, National Infection Service, Public Health England, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Manchester, UK.
出版信息
Methods Mol Biol. 2019;1969:169-179. doi: 10.1007/978-1-4939-9202-7_12.
Serum bactericidal antibody (SBA) assays measure functional antibody titers against Neisseria meningitidis in sera. Induction of complement-dependent SBA after vaccination with meningococcal polysaccharide or conjugate or protein based vaccines is regarded as the surrogate of protection and thus acceptable evidence of the potential efficacy of these vaccines. This chapter discusses and details SBA assay protocols for measuring the complement-mediated lysis of serogroup A, B, C, W, X, and Y meningococci by human sera, for example, following vaccination or disease.
血清杀菌抗体（SBA）检测可测定血清中针对脑膜炎奈瑟菌的功能性抗体滴度。接种脑膜炎球菌多糖疫苗、结合疫苗或蛋白疫苗后诱导产生的补体依赖性SBA被视为保护作用的替代指标，因此也是这些疫苗潜在效力的可接受证据。本章讨论并详细介绍了SBA检测方案，该方案用于检测人血清对A、B、C、W、X和Y群脑膜炎球菌的补体介导裂解作用，例如在接种疫苗后或患病后进行检测。
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