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在卵泡中期通过脉冲式注射促黄体生成素释放激素刺激多个卵泡生长用于体外受精。

Stimulation of multiple follicular growth for in vitro fertilization by administration of pulsatile luteinizing hormone-releasing hormone during the midfollicular phase.

作者信息

Shaw R W, Ndukwe G, Imoedemhe D, Burford G, Chan R

出版信息

Fertil Steril. 1986 Jul;46(1):135-7. doi: 10.1016/s0015-0282(16)49472-0.

DOI:10.1016/s0015-0282(16)49472-0
PMID:3087787
Abstract

Pulsatile subcutaneous administration of LH-RH (14.4 micrograms/pulse/90 minutes) during the midfollicular phase (days 7 to 11) of the cycle induced significant increases in circulating LH, FSH, and E2 in all eight women treated. When CC (150 mg/day on days 2 to 6) was administered prior to the LH-RH, multiple follicular development occurred, five to seven mature follicles (greater than 16 mm) being found on day 12 of the cycle. The administration of pulsatile LH-RH in this manner may prove to be an additional regimen for use in IVF programs.

摘要

在月经周期的卵泡中期（第7至11天），对8名接受治疗的女性进行促黄体生成激素释放激素（LH-RH）的皮下脉冲给药（14.4微克/脉冲/90分钟），可使所有女性的循环促黄体生成素（LH）、促卵泡生成素（FSH）和雌二醇（E2）显著增加。当在LH-RH给药前给予克罗米芬（CC，第2至6天每天150毫克）时，出现了多个卵泡发育，在周期的第12天发现了5至7个成熟卵泡（大于16毫米）。以这种方式进行脉冲式LH-RH给药可能被证明是体外受精（IVF）方案中可采用的另一种治疗方案。

相似文献

1
Stimulation of multiple follicular growth for in vitro fertilization by administration of pulsatile luteinizing hormone-releasing hormone during the midfollicular phase.在卵泡中期通过脉冲式注射促黄体生成素释放激素刺激多个卵泡生长用于体外受精。
Fertil Steril. 1986 Jul;46(1):135-7. doi: 10.1016/s0015-0282(16)49472-0.
2
Attempts to stimulate multiple follicular growth for IVF by administration of pulsatile LHRH.通过给予脉冲式促黄体生成素释放激素（LHRH）来刺激多个卵泡生长用于体外受精（IVF）的尝试。
Clin Reprod Fertil. 1987 Jun;5(3):141-51.
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Dynamics of the development of multiple follicles during ovarian stimulation for in vitro fertilization using recombinant follicle-stimulating hormone (Puregon) and various doses of the gonadotropin-releasing hormone antagonist ganirelix (Orgalutran/Antagon).使用重组促卵泡激素（普丽康）和不同剂量促性腺激素释放激素拮抗剂加尼瑞克（奥加奴肽/拮抗剂）进行体外受精卵巢刺激期间多个卵泡发育的动态变化
Fertil Steril. 2001 Apr;75(4):688-93. doi: 10.1016/s0015-0282(00)01789-1.
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The frequency of pulsatile luteinizing hormone-releasing hormone treatment and luteinizing hormone and follicle-stimulating hormone secretion in women with amenorrhea of suprapituitary origin.
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Gonadotropins and estradiol responses to single intranasal or subcutaneous administration of a luteinizing hormone-releasing hormone agonist in the early follicular phase.卵泡早期单次经鼻或皮下注射促黄体生成素释放激素激动剂后促性腺激素和雌二醇的反应
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Increased frequency of pulsatile luteinizing hormone-releasing hormone administration selectively decreases follicle-stimulating hormone levels in men with idiopathic azoospermia.增加脉冲式促黄体生成激素释放激素的给药频率可选择性降低特发性无精子症男性的促卵泡生成素水平。
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Effect of mifepristone (RU486) on the pituitary response to gonadotrophin releasing hormone in women.米非司酮（RU486）对女性垂体对促性腺激素释放激素反应的影响。
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Variable tolerance of the developing follicle and corpus luteum to gonadotropin-releasing hormone antagonist-induced gonadotropin withdrawal in the human.发育中的卵泡和黄体对促性腺激素释放激素拮抗剂诱导的人促性腺激素撤退的可变耐受性。
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Even after priming with ovarian steroids or pulsatile gonadotropin-releasing hormone administration, naltrexone is unable to induce ovulation in women with functional hypothalamic amenorrhea.即使在使用卵巢甾体激素进行预处理或脉冲式给予促性腺激素释放激素后，纳曲酮仍无法诱导功能性下丘脑性闭经女性排卵。
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A pilot study involving minimal ovarian stimulation for in vitro fertilization: extending the "follicle-stimulating hormone window" combined with the gonadotropin-releasing hormone antagonist cetrorelix.一项关于体外受精中最小化卵巢刺激的初步研究：结合促性腺激素释放激素拮抗剂西曲瑞克延长“促卵泡激素窗口”
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引用本文的文献

1
Pharmacological interventions for the induction of ovulation.诱导排卵的药物干预措施。
Drugs. 1995 Sep;50(3):480-94. doi: 10.2165/00003495-199550030-00006.
2
The sequential use of a luteinizing hormone-releasing hormone (LH-RH) agonist and human menopausal gonadotropins to stimulate folliculogenesis in patients with resistant ovaries.序贯使用促黄体生成激素释放激素（LH-RH）激动剂和人绝经后促性腺激素以刺激耐药卵巢患者的卵泡生成。
J In Vitro Fert Embryo Transf. 1988 Feb;5(1):38-42. doi: 10.1007/BF01138869.
3
Drugs used in in vitro fertilisation procedures.
体外受精程序中使用的药物。
Drugs. 1989 Jul;38(1):148-59. doi: 10.2165/00003495-198938010-00006.
4
Ovarian stimulation for in vitro fertilization in low-responder patients using pulsatile intravenous follicle stimulating hormone.
J In Vitro Fert Embryo Transf. 1990 Oct;7(5):275-9. doi: 10.1007/BF01129534.
5
Ovarian stimulation for in vitro fertilization using pure follicle-stimulating hormone with and without gonadotropin-releasing hormone agonist in high-responder patients.在高反应患者中使用纯促卵泡激素联合或不联合促性腺激素释放激素激动剂进行体外受精的卵巢刺激。
J In Vitro Fert Embryo Transf. 1990 Jun;7(3):172-6. doi: 10.1007/BF01135684.