Seidel H J, Kreja L
Folia Histochem Cytobiol. 1986;24(1):27-31.
T cell leukemias were induced in BDF 1 mice by methylnitrosourea (MNU). The phenotype of the leukemic cells is Thy1.2 +, PNA-, TdT+, TL+ and heterogeneous with respect to Lyt-1 and Lyt-2. About 70% of the leukemias have elevated amounts of gp70. During latency period of at least 9 + 12 weeks an early reduction in the various thymic cells and the CFU-S is observed, with almost complete recovery. Later PNA+ cells are reduced. Hydrocortisone treatment delays or enhances leukemogenesis, dependent on the time interval between hydrocortisone and MNU. Some mice show elevated amounts of gp70 in their bone marrow 2--3 weeks after MNU. The problem of target cells in the bone marrow and the thymus is discussed.
用甲基亚硝基脲（MNU）在BDF1小鼠中诱发T细胞白血病。白血病细胞的表型为Thy1.2 +、PNA-、TdT+、TL+，且Lyt-1和Lyt-2呈异质性。约70%的白血病中gp70含量升高。在至少9 + 12周的潜伏期内，观察到各种胸腺细胞和脾集落形成单位（CFU-S）早期减少，几乎完全恢复。后期PNA+细胞减少。氢化可的松治疗根据氢化可的松与MNU之间的时间间隔延迟或增强白血病发生。一些小鼠在MNU处理后2 - 3周骨髓中gp70含量升高。讨论了骨髓和胸腺中的靶细胞问题。
