Seidel H J, Kreja L
Leuk Res. 1985;9(5):625-9. doi: 10.1016/0145-2126(85)90143-2.
T-cell leukemias were induced in adult BDF1 mice by a single i.v. injection of methylnitrosourea (MNU). Leukemogenesis was delayed by a single or repeated injections of hydrocortisone (HC) after MNU and also when HC was given one day before MNU. Enhancement of leukemogenesis was seen in experiments with 10 and 14 days' intervals between HC and MNU. The T-cell subset composition of the thymus after HC treatment was studied at these time intervals, but a specific target cell for the action of MNU, reduced one day after HC and increased in number during the thymic regeneration at 10 and 14 days could not be defined. HC did not prohibit the toxic action of MNU as measured by hemopoietic stem cell numbers in the femur.
通过静脉内单次注射甲基亚硝基脲（MNU）在成年BDF1小鼠中诱导T细胞白血病。在MNU注射后单次或重复注射氢化可的松（HC）时，白血病发生延迟，并且当在MNU前一天给予HC时也是如此。在HC和MNU之间间隔10天和14天的实验中观察到白血病发生增强。在这些时间间隔研究了HC处理后胸腺的T细胞亚群组成，但无法确定MNU作用的特定靶细胞，该靶细胞在HC后一天减少，在10天和14天胸腺再生期间数量增加。通过股骨中的造血干细胞数量测量，HC并未抑制MNU的毒性作用。
