Skjöldebrand L, Brundin J, Carlström A, Pettersson T
Gynecol Obstet Invest. 1986;21(4):187-92. doi: 10.1159/000298952.
Thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), thyroxine (T4), free T4, triiodothyronine (T3) and thyroid-stimulating hormone (TSH) were studied in 144 apparently healthy, euthyroid pregnant women displaying miscarriages. In an additional group of 18 aborting women a frozen blood sample drawn in early pregnancy was similarly analyzed for the thyroid components as well as for human chorionic gonadotropin (HCG). The values were compared to those of normal pregnancies (n = 228) at corresponding intervals. Significantly lower values of TBG were found in the spontaneously aborting group. A significantly lower value of TBG was found to be more predictive concerning spontaneous abortion than that of HCG.
对144名表面健康、甲状腺功能正常但有流产史的孕妇进行了甲状腺素结合球蛋白（TBG）、甲状腺素结合前白蛋白（TBPA）、甲状腺素（T4）、游离T4、三碘甲状腺原氨酸（T3）和促甲状腺激素（TSH）的研究。在另外一组18名流产妇女中，对她们孕早期采集的冷冻血样同样进行了甲状腺成分以及人绒毛膜促性腺激素（HCG）的分析。将这些值与相应孕周的正常妊娠组（n = 228）的值进行比较。自发流产组的TBG值显著更低。结果发现，与HCG相比，TBG值显著降低对于自然流产更具预测性。
