Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China.
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, PR China.
J Neuroimmunol. 2019 May 15;330:136-142. doi: 10.1016/j.jneuroim.2019.03.001. Epub 2019 Mar 1.
Paraneoplastic myelopathy is rare paraneoplastic neurological syndromes. We reviewed patients through medical records system and screened patients who presented with myelopathy, and/or coexisting cancer, and/or onconeural antibodies. Nine patients were identified as paraneoplastic myelopathy presenting with progressive subacute (2/9) or insidious (7/9) myelopathy. CSF abnormalities included elevated protein, 5; pleocytosis, 4; excess oligoclonal bands, 6. Seven patients had onconeural antibody. Cancer was confirmed histopathologically in 6 and diagnosed by PET-CT in 1. Four patients had symmetric, longitudinally extensive grey matter or tract-specific changes on spinal cord MRI. It was associated with significant morbidity and had poor response to treatment.
副肿瘤性脊髓病是罕见的副肿瘤性神经系统综合征。我们通过病历系统进行了患者回顾，并筛选出表现为脊髓病、合并癌症、和/或存在肿瘤相关抗体的患者。共发现 9 例副肿瘤性脊髓病患者，表现为进行性亚急性（2/9）或隐匿性（7/9）脊髓病。CSF 异常包括蛋白升高 5 例；细胞增多 4 例；寡克隆条带增加 6 例。7 例患者存在肿瘤相关抗体。6 例患者通过组织病理学确诊，1 例患者通过 PET-CT 确诊。4 例患者的脊髓 MRI 显示对称性、广泛性灰质或特定部位病变。副肿瘤性脊髓病与较高的发病率相关，且对治疗反应不佳。
