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Guidelines for Finite-Element Modeling of Acoustic Radiation Force-Induced Shear Wave Propagation in Tissue-Mimicking Media.声学辐射力诱发组织模拟介质中剪切波传播的有限元建模指南。
IEEE Trans Ultrason Ferroelectr Freq Control. 2017 Jan;64(1):78-92. doi: 10.1109/TUFFC.2016.2641299. Epub 2016 Dec 21.
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An Inverse Method to Determine Arterial Stiffness with Guided Axial Waves.一种利用引导轴向波确定动脉僵硬度的逆方法。
Ultrasound Med Biol. 2017 Feb;43(2):505-516. doi: 10.1016/j.ultrasmedbio.2016.10.006. Epub 2016 Nov 28.
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Controlling elastic wave propagation in a soft bilayer system via wrinkling-induced stress patterns.通过褶皱诱导的应力模式控制软双层系统中的弹性波传播。
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Functionally graded materials for orthopedic applications - an update on design and manufacturing.用于矫形应用的功能梯度材料——设计和制造的最新进展。
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Arterial Stiffness Estimation by Shear Wave Elastography: Validation in Phantoms with Mechanical Testing.通过剪切波弹性成像技术估计动脉僵硬度:在机械测试模型中的验证
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超声弹性成像技术对功能梯度软材料的力学特性进行研究。

Mechanical characterization of functionally graded soft materials with ultrasound elastography.

机构信息

1 AML, Department of Engineering Mechanics, Institute of Biomechanics and Medical Engineering, Tsinghua University , Beijing 100084 , People's Republic of China.

2 Beijing Center for Physical and Chemical Analysis , Beijing 100089 , People's Republic of China.

出版信息

Philos Trans A Math Phys Eng Sci. 2019 May 6;377(2144):20180075. doi: 10.1098/rsta.2018.0075.

DOI:10.1098/rsta.2018.0075
PMID:30879421
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6452040/
Abstract

Functionally graded soft materials (FGSMs) with microstructures and mechanical properties exhibiting gradients across a spatial volume to satisfy specific functions have received interests in recent years. How to characterize the mechanical properties of these FGSMs in vivo/in situ and/or in a non-destructive manner is a great challenge. This paper investigates the use of ultrasound elastography in the mechanical characterization of FGSMs. An efficient finite-element model was built to calculate the dispersion relation for surface waves in FGSMs. For FGSMs with large elastic gradients, the measured dispersion relation can be used to identify mechanical parameters. In the case where the elastic gradient is smaller than a certain critical value calculated here, our analysis on transient wave motion in FGSMs shows that the group velocities measured at different depths can infer the local mechanical properties. Experiments have been performed on polyvinyl alcohol (PVA) cryogel to demonstrate the usefulness of the method. Our analysis and the results may not only find broad applications in mechanical characterization of FGSMs but also facilitate the use of shear wave elastography in clinics because many diseases change the local elastic properties of soft tissues and lead to different material gradients. This article is part of the theme issue 'Rivlin's legacy in continuum mechanics and applied mathematics'.

摘要

近年来,具有微结构和机械性能梯度分布的功能梯度软材料(FGSMs)受到了广泛关注,这些梯度分布可以满足特定的功能。如何在体内/原位和/或非破坏性的方式下对这些 FGSMs 的机械性能进行特征化是一个巨大的挑战。本文研究了超声弹性成像在 FGSMs 机械特性表征中的应用。建立了一种有效的有限元模型来计算 FGSMs 中表面波的频散关系。对于弹性梯度较大的 FGSMs,可以使用测量的频散关系来识别机械参数。在弹性梯度小于此处计算的某个临界值的情况下,我们对 FGSMs 中瞬态波运动的分析表明,在不同深度测量的群速度可以推断出局部机械性能。已经在聚乙烯醇(PVA)冷冻凝胶上进行了实验,以证明该方法的有用性。我们的分析和结果不仅可以在 FGSMs 的机械特性表征中找到广泛的应用,而且可以促进剪切波弹性成像在临床上的应用,因为许多疾病会改变软组织的局部弹性特性,并导致不同的材料梯度。本文是主题为“Rivlin 在连续介质力学和应用数学中的遗产”的一部分。