Skin Diseases and Leishmaniasis Research Center, Isfahan University Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Biol Trace Elem Res. 2019 Dec;192(2):145-152. doi: 10.1007/s12011-019-01672-z. Epub 2019 Mar 18.
A number of studies have assessed the association between serum magnesium (Mg) and premenstrual syndrome (PMS) in different population, but the findings have been inconclusive. Herein, we systematically reviewed available observational studies to elucidate the overall relationship between Mg and PMS. PubMed, Cochrane's library, ScienceDirect, Scopus, Google Scholar, and ISI web of science databases were searched for all available literature until January 2019 for studies evaluating the association between Mg and PMS. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of observational studies. A total of 13 studies out of 196 met our inclusion criteria and were included in our systematic review and meta-analysis. There were no associations between serum magnesium and PMS (WMD - 0.04; 95% CI, - 0.14 to 0.06; P = 0.46) during follicular or serum/erythrocyte magnesium (WMD - 0.37; 95% CI, - 1.01 to 0.27; P = 0.25)/(WMD - 0.04; 95% CI, - 0.10 to 0.03; P = 0.26) and during luteal phase except for the sub-group of studies done outside of the US in which recent association became significant and means that serum Mg is lower in PMS subjects. According to what have been discussed, although our study did not show any significant association between serum/erythrocyte Mg and PMS except for serum Mg in luteal phase in the sub-group of studies done outside of the USA, heterogeneity between studies should be taken into accounts when interpreting these results. Additional well-designed clinical trials should be considered in future research to develop firm conclusions on the efficacy of magnesium on PMS.Registration number: CRD42018114473 .
一些研究评估了血清镁（Mg）与经前综合征（PMS）在不同人群中的关系，但结果尚无定论。在此，我们系统地回顾了现有的观察性研究，以阐明 Mg 与 PMS 之间的总体关系。我们检索了 PubMed、Cochrane 图书馆、ScienceDirect、Scopus、Google Scholar 和 ISI web of science 数据库，以获取所有评估 Mg 与 PMS 之间关系的可用文献，截至 2019 年 1 月。使用纽卡斯尔-渥太华质量评估量表评估观察性研究的质量。在 196 项研究中，共有 13 项符合我们的纳入标准，并纳入了我们的系统评价和荟萃分析。在卵泡期或血清/红细胞镁（WMD -0.04；95%CI，-0.14 至 0.06；P=0.46）或黄体期（WMD -0.37；95%CI，-1.01 至 0.27；P=0.25）/（WMD -0.04；95%CI，-0.10 至 0.03；P=0.26）期间，血清镁与 PMS 之间没有关联，但在美国以外的研究中，最近的关联变得显著，这意味着 PMS 患者的血清镁水平较低。根据上述讨论，尽管我们的研究除了在美国以外的研究中黄体期血清镁外，没有显示血清/红细胞 Mg 与 PMS 之间存在任何显著关联，但在解释这些结果时应考虑研究之间的异质性。未来的研究应考虑进行更多设计良好的临床试验，以对镁治疗 PMS 的疗效得出明确结论。注册号：CRD42018114473。
