As Habi Atefeh, Sadeghi Malihe, Arab Arman, Hajianfar Hossein
Food Safety Research Center (SALT), Semnan University of Medical Sciences, Semnan, Iran.
Department of Nutrition, School of Nutrition and Food Sciences, Semnan University of Medical Sciences , Semnan, Iran.
Diabetes Metab Syndr Obes. 2019 Jul 31;12:1277-1286. doi: 10.2147/DMSO.S206981. eCollection 2019.
A number of studies have examined the association between the serum levels of omentin and diabetes, but the findings have been inconclusive. Herein, we systematically reviewed available observational studies to elucidate the overall relationship between omentin and diabetes, including type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and impaired glucose tolerance (IGT) among adolescent and adult population.
PubMed, Cochrane's Library, Science Direct, Scopus, Google Scholar, and ISI Web of Science databases were searched for all available literature until January 2019 for studies assessing the association between omentin and diabetes. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of each study.
A total of 28 articles met the inclusion criteria and were included in our systematic review and meta-analysis. There was a significant association between serum omentin and diabetes (WMD-1.68; 95% CI, -2.17 to -1.19; <0.001). The result of our sub-group analysis based on participants' health status revealed that omentin was significantly lower in T2DM and IGT subjects but not in T1DM ones compared to healthy controls.
We found that serum omentin level is significantly lower in T2DM and IGT patients but not in T1DM ones. These data could be used by clinicians for early diagnosis and management of diabetes. Furthermore, we need more clinical trials to investigate new agents which could influence omentin levels.
多项研究探讨了血清网膜素水平与糖尿病之间的关联，但结果尚无定论。在此，我们系统回顾了现有的观察性研究，以阐明网膜素与糖尿病之间的总体关系，包括青少年和成年人群中的1型糖尿病（T1DM）、2型糖尿病（T2DM）和糖耐量受损（IGT）。
检索了PubMed、Cochrane图书馆、Science Direct、Scopus、谷歌学术和ISI科学网数据库，以查找截至2019年1月所有评估网膜素与糖尿病之间关联的可用文献。采用纽卡斯尔-渥太华质量评估量表评估每项研究的质量。
共有28篇文章符合纳入标准，并被纳入我们的系统评价和荟萃分析。血清网膜素与糖尿病之间存在显著关联（加权均数差为-1.68；95%可信区间为-2.17至-1.19；P<0.001）。基于参与者健康状况的亚组分析结果显示，与健康对照组相比，T2DM和IGT受试者的网膜素显著降低，但T1DM受试者的网膜素无显著降低。
我们发现T2DM和IGT患者的血清网膜素水平显著降低，但T1DM患者并非如此。这些数据可供临床医生用于糖尿病的早期诊断和管理。此外，我们需要更多的临床试验来研究可能影响网膜素水平的新药物。
