生存素-31G>C基因多态性与中国南方人群散发性结直肠癌易感性的关系。
The association between survivin -31G>C polymorphism and susceptibility to sporadic colorectal cancer in a Southern Chinese population.
作者信息
Huang Jun, Wei Yisheng, Zhou Xiaodong, Wang Lei, Huang Meijin, Wang Jianping
机构信息
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006; Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, China.
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, China.
出版信息
J Cancer Res Ther. 2019 Jan-Mar;15(1):82-86. doi: 10.4103/0973-1482.202894.
BACKGROUND
The case-control study aimed to investigate the association between the -31G>C polymorphism in the promoter of survivin gene and the susceptibility to sporadic colorectal cancer (CRC) in a Southern Chinese population.
MATERIALS AND METHODS
The study was carried out on 711 healthy controls and 702 CRC cases of a Southern Chinese population. Survivin gene -31G>C genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. The association between CRC risk and -31G>C genetic polymorphism was estimated using an unconditional logistic regression model.
RESULTS
The number of CC genotype carried in CRC patients was much higher than those of controls (P < 0.001). Compared with CC genotypes, GC, GG genotypes and -31G wild-type genotypes (i.e., GC + GG) had a significantly decreased risk of CRC (P < 0.001). In addition, survivin -31G wild-type genotypes were not associated with decreased risk of sporadic CRC patients with body mass index (BMI) ≥28.0 kg/m, family cancer history, and premenopausal.
CONCLUSION
Survivin -31G>C polymorphism is associated with sporadic CRC risk in the Southern Chinese population. The -31G wild-type genotypes and GC, GG genotypes are the independent protective factors against sporadic CRC excluding those with a BMI ≥28.0 kg/m, family cancer history, and premenopausal.
背景
本病例对照研究旨在调查生存素基因启动子区 -31G>C 多态性与中国南方人群散发性结直肠癌（CRC）易感性之间的关联。
材料与方法
对 711 名健康对照者和 702 例中国南方人群的 CRC 患者进行了研究。采用聚合酶链反应 - 限制性片段长度多态性方法确定生存素基因 -31G>C 基因型。使用非条件逻辑回归模型评估 CRC 风险与 -31G>C 基因多态性之间的关联。
结果
CRC 患者中携带 CC 基因型的人数远高于对照组（P < 0.001）。与 CC 基因型相比，GC、GG 基因型以及 -31G 野生型基因型（即 GC + GG）的 CRC 风险显著降低（P < 0.001）。此外，生存素 -31G 野生型基因型与体重指数（BMI）≥28.0 kg/m、有家族癌症病史以及绝经前的散发性 CRC 患者风险降低无关。
结论
生存素 -31G>C 多态性与中国南方人群散发性 CRC 风险相关。-31G 野生型基因型以及 GC、GG 基因型是排除 BMI≥28.0 kg/m、有家族癌症病史以及绝经前患者之外的散发性 CRC 的独立保护因素。
Zotero 插件