生存素基因功能性启动子-31G/C变异体对中国人群前列腺癌易感性的预测：一项病例对照研究
Functional promoter -31G/C variant of Survivin gene predict prostate cancer susceptibility among Chinese: a case control study.
作者信息
Chen Jiawei, Cui Xinhai, Zhou Hai, Qin Chao, Cao Qiang, Ju Xiaobing, Li Pu, Cai Hongzhou, Zhu Jian, Meng Xiaoxin, Wang Meilin, Zhang Zhengdong, Shao Pengfei, Li Jie, Yin Changjun
机构信息
State Key Laboratory of Reproductive Medicine, Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 300 Guangzhou Road, Nanjing 210029, China.
出版信息
BMC Cancer. 2013 Jul 24;13:356. doi: 10.1186/1471-2407-13-356.
BACKGROUND
Abnormal expression of Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5, also called as survivin), a novel member of the inhibitor of apoptosis protein (IAP) family, has implications in many types of cancer and is considered as a new therapeutic target. We suppose that genetic variant rs9904341 in the 5' UTR region of survivin gene may be associated with the development and progression of prostate cancer (PCa) in Chinese population.
METHODS
TaqMan assay method was used to genotype the polymorphism in the hospital-based case-control analysis of 665 patients with PCa and 710 age-matched cancer-free controls. The genetic associations with the occurrence and progression of PCa were calculated by logistic regression.
RESULTS
Our results indicated that compared with GG genotypes, there was a statistically significant increased risk of PCa associated with those with CC genotypes [odds ratios (ORs) = 1.57, 95%confidence intervals (CIs) = 1.17-2.13, P = 0.004]. Moreover, stratification analysis revealed that the association was more pronounced in subgroups of nondrinkers, nonsmokers and those without a family history of cancer (all P < 0.05). In addition, we observed that PSA ≥ 20 was more frequent in patients carrying GC/CC genotypes than in those with a wild type genotype.
CONCLUSION
The functional survivin rs9904341 genetic variant may have a substantial influence on the PCa susceptibility and evolution.
背景
杆状病毒凋亡抑制蛋白重复序列包含5（BIRC5，也称为存活素）是凋亡抑制蛋白（IAP）家族的一个新成员，其异常表达与多种癌症相关，被认为是一个新的治疗靶点。我们推测存活素基因5'UTR区域的遗传变异rs9904341可能与中国人群前列腺癌（PCa）的发生和发展有关。
方法
采用TaqMan检测方法对665例PCa患者和710例年龄匹配的无癌对照进行基于医院的病例对照分析，对该多态性进行基因分型。通过逻辑回归计算与PCa发生和发展的遗传关联。
结果
我们的结果表明，与GG基因型相比，CC基因型个体患PCa的风险在统计学上显著增加[比值比（ORs）=1.57，95%置信区间（CIs）=1.17-2.13，P=0.004]。此外，分层分析显示，在不饮酒者、不吸烟者和无癌症家族史的亚组中，这种关联更为明显（所有P<0.05）。此外，我们观察到携带GC/CC基因型的患者中PSA≥20的情况比野生型基因型患者更常见。
结论
功能性存活素rs9904341基因变异可能对PCa易感性和进展有重大影响。
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