Wang Aihua, Du Lei, Jiang Kaitong, Kong Qingyin, Zhang Xiutian, Li Luning
Department of Gastroenterology, Linyi People's Hospital, Linyi, Shandong, China.
Department of Oncology, Linyi People's Hospital, Linyi, Shandong, China.
J Cancer Res Ther. 2019 Jan-Mar;15(1):126-131. doi: 10.4103/0973-1482.204882.
Long noncoding RNAs (lncRNAs) have been shown to have a fundamental role in cancer initiation and development. LncRNA microvascular invasion in hepatocellular carcinoma (MVIH) has been identified as a potential prognostic marker in several cancers; however, its role in gastric cancer (GC) has not been elucidated.
A total of 152 tissue samples from patients underwent GC surgical resection in Linyi People's Hospital between 2007 and 2010 were collected. Quantitative real-time polymerase chain reaction was conducted to examine the expression level of lncRNA MVIH. The selection of clinically important cut-off scores for MVIH expression was based on receiver operating characteristic curve analysis. Then, the association between MVIH and GC clinicopathological parameters was analyzed. Moreover, univariate and multivariate Cox regression analysis were performed to reveal the relationship between MVIH and GC prognosis.
GC tissues exhibited a higher lncRNA MVIH expression level than paired nontumoros tissues. High MVIH level was revealed to be associated with the T stage, tumor-node-metastasis (TNM) stage and lymphatic metastasis of GC. Specially, patients with high MVIH expression level showed significantly shorter overall survival rate and progression-free survival rate. Moreover, invasion depth, distant metastasis, TNM stage, and MVIH expression were identified as risk factors of GC poor prognosis on univariate Cox regression analyses. By further analyzing these factors with multivariate logistic regression, high MVIH, and distant metastasis were discovered to be independent risk factors of GC prognosis.
High MVIH is an independent risk factor of GC prognosis. LncRNA MVIH may serve as a potential therapeutic target and a prognostic marker of GC patients.
长链非编码RNA（lncRNA）已被证明在癌症的发生和发展中起重要作用。肝细胞癌微血管侵袭相关lncRNA（MVIH）已被确定为几种癌症的潜在预后标志物；然而，其在胃癌（GC）中的作用尚未阐明。
收集2007年至2010年期间在临沂市人民医院接受GC手术切除的152例患者的组织样本。采用定量实时聚合酶链反应检测lncRNA MVIH的表达水平。MVIH表达的临床重要临界值的选择基于受试者工作特征曲线分析。然后，分析MVIH与GC临床病理参数之间的关联。此外，进行单因素和多因素Cox回归分析以揭示MVIH与GC预后之间的关系。
GC组织中lncRNA MVIH的表达水平高于配对的非肿瘤组织。高MVIH水平与GC的T分期、肿瘤-淋巴结-转移（TNM）分期和淋巴转移相关。特别是，MVIH表达水平高的患者总生存率和无进展生存率显著缩短。此外，在单因素Cox回归分析中，浸润深度、远处转移、TNM分期和MVIH表达被确定为GC预后不良的危险因素。通过多因素逻辑回归进一步分析这些因素，发现高MVIH和远处转移是GC预后的独立危险因素。
高MVIH是GC预后的独立危险因素。LncRNA MVIH可能作为GC患者的潜在治疗靶点和预后标志物。
