Guo Jun, Liang Lei, Zhou Nan, Li De-Yu
School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
Department of Ultrasound, Aero Space Central Hospital, Beijing, 100049, China.
Urol J. 2019 Aug 18;16(4):347-351. doi: 10.22037/uj.v0i0.4224.
This study aims to evaluate the value of quantitative analysis of ultrasound real-time tissue diffusion elastography in the diagnosis of benign and malignant prostate lesions.
From March 2010 to June 2013, 52 patients suspected with prostate cancer based on laboratory or clinical test results and underwent prostate biopsy in our hospital were enrolled into this study. The age of these patients ranged between 45-82 years, with an average age of 67.2 ± 6.8 years. All patients underwent transrectal real-time ultrasound elastography (TRTE) before biopsy. A total of 63 prostate nodules were detected, and the 11 elastic characteristic quantities of these nodules were quantitatively analyzed via tissue diffusion quantitative analysis. The results of ultrasonography were compared with the results of operation and pathology.
Among these 11 characteristic quantities, which include the mean (MEAN) and standard deviation (SD), blue area ratio (AREA%), complexity (COMP), kurtosis (KURT), skewness (SKEW), contrast (CONT), equality (ENT), entropy (IDM), consistency (ASM) and correlation (CORR), except for COMP and CORR, the differences in other nine characteristic quantities between benign and malignant prostatic nodules were statistically significant (P<0.05). Among these, the AREA% and MEAN had the highest correlation, which were 0.791 and -0.791, respectively. The Youden's index (sensitivity and specificity) of AREA% in the ROC curves was the highest, the cutoff value was 80.65% for the diagnosis of prostate cancer, sensitivity was 87.9%, and specificity was 96.6%.
Quantitative analysis of ultrasound real-time tissue diffusion elastography is helpful in the diagnosis of benign and malignant prostate lesions, provides a relatively accurate evaluation method in clinical practice, and has broad application prospects.
本研究旨在评估超声实时组织弥散弹性成像定量分析在前列腺良恶性病变诊断中的价值。
选取2010年3月至2013年6月间，因实验室或临床检查结果怀疑患有前列腺癌且在我院接受前列腺穿刺活检的52例患者。这些患者年龄在45 - 82岁之间，平均年龄为67.2±6.8岁。所有患者在活检前均接受经直肠实时超声弹性成像（TRTE）检查。共检测到63个前列腺结节，并通过组织弥散定量分析对这些结节的11个弹性特征量进行了定量分析。将超声检查结果与手术及病理结果进行比较。
在这11个特征量中，包括均值（MEAN）、标准差（SD）、蓝色区域比例（AREA%）、复杂度（COMP）、峰度（KURT）、偏度（SKEW）、对比度（CONT）、均匀度（ENT）、熵（IDM）、一致性（ASM）和相关性（CORR），除COMP和CORR外，其余9个特征量在前列腺良性和恶性结节之间的差异具有统计学意义（P<0.05）。其中，AREA%与MEAN的相关性最高，分别为0.791和 -0.791。ROC曲线中AREA%的约登指数（敏感性和特异性）最高，诊断前列腺癌的截断值为80.65%，敏感性为87.9%，特异性为96.6%。
超声实时组织弥散弹性成像定量分析有助于前列腺良恶性病变的诊断，在临床实践中提供了一种相对准确的评估方法，具有广阔的应用前景。
