Laboratory of Neurophysiology, Department of Physiology, Universidad de Concepcion, Concepcion, Chile.
Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
Addict Biol. 2020 Mar;25(2):e12726. doi: 10.1111/adb.12726. Epub 2019 Mar 18.
Here, we used knock-in (KI) mice that have ethanol-insensitive alpha 1 glycine receptors (GlyRs) (KK385/386AA) to examine how alpha 1 GlyRs might affect binge drinking and conditioned place preference. Data show that tonic alpha 1 GlyR-mediated currents were exclusively sensitive to ethanol only in wild-type mice. Behavioral studies showed that the KI mice have a higher intake of ethanol upon first exposure to drinking and greater conditioned place preference to ethanol. This study suggests that nonsynaptic alpha 1-containing GlyRs have a role in motivational and early reinforcing effects of ethanol.
在这里，我们使用 knock-in (KI) 小鼠，这些小鼠具有对乙醇不敏感的 alpha 1 甘氨酸受体 (GlyRs) (KK385/386AA)，以研究 alpha 1 GlyRs 如何影响狂饮和条件性位置偏好。数据表明，在野生型小鼠中，只有 tonic alpha 1 GlyR 介导的电流对乙醇具有特异性敏感性。行为研究表明，KI 小鼠在首次接触饮酒时摄入更多的乙醇，并且对乙醇的条件性位置偏好更大。这项研究表明，非突触 alpha 1 含 GlyRs 在乙醇的动机和早期强化作用中发挥作用。
