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中国高危及老年患者经尿道双极等离子体前列腺切除术治疗良性前列腺增生:一项系统评价与荟萃分析

[Transurethral bipolar plasmakinetic prostatectomy for benign prostatic hyperplasia in high-risk and senior patients in China: a systematic review and meta-analysis].

作者信息

Zhang Z Y, Zhao M J, Hong B A, Ma L L, Jin Y H, Zeng X T, Gong K

机构信息

Department of Urology, the First Hospital of Peking University, Beijing 100034, China.

Department of Cardiology, the Fist Affiliated Hospital of Henan University, Kaifeng 475004, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2019 Mar 12;99(10):778-782. doi: 10.3760/cma.j.issn.0376-2491.2019.10.015.

Abstract

To evaluate the effectiveness and safety of transurethral bipolar plasmakinetic prostatectomy in the treatment of benign prostatic hyperplasia in high-risk and senior patients in China. The PubMed, Cochrane Library, CBM, CNKI and WanFang databases were searched with computer for collecting relevant interventional case series from establishment dates to September 14, 2018. After quality evaluation and data extraction independently conducted by two authors, the Meta-analysis was performed using the Comprehensive Meta-analysis V2 software. Eighteen studies involving 1 899 patients are included. Maximum flow rate increased to 12.28 ml/s (95: 8.42-16.14), 12.88 ml/s (95: 9.85-15.92) ,14.32 ml/s (95: 10.47-18.18), 14.93 ml/s (95: 10.19-19.67) and 20.00 ml/s (95: 19.08-20.92) in 1, 3, 6, 12 and 24 months after surgery, respectively. International prostate symptom score decreased to -18.60 (95: -23.20--14.00), -17.62 (95: -20.21--15.03), -19.14 (95: -20.70--17.59), -19.06 (95: -21.53--16.60) and -22.90 (95: -24.26--21.54), respectively. Quality of life decreased to -2.38 (95: -4.26--0.50), -3.39 (95: -4.57--2.21),-3.75 (95: -4.14--3.36), -3.36(95: -4.56--2.16), and -4.58(95: -4.75--4.41). Post void residual decreased to -231.16 ml (95: -288.30--174.01), -76.10 ml (95: -116.71--35.50), -159.90 ml(95: -207.21--112.59) and -87.70 ml (95: -91.91--83.48). The event rate of postoperative adverse reactions all were not high. Transurethral bipolar plasmakinetic prostatectomy has better clinical efficacy and no obvious side effects in the treatment of benign prostatic hyperplasia in high-risk and senior patients in China.

摘要

评估经尿道双极等离子体前列腺切除术治疗中国高危及老年良性前列腺增生患者的有效性和安全性。通过计算机检索PubMed、Cochrane图书馆、中国生物医学文献数据库、中国知网和万方数据库,收集从建库至2018年9月14日的相关干预性病例系列。经两位作者独立进行质量评估和数据提取后,使用Comprehensive Meta-analysis V2软件进行Meta分析。纳入18项研究,共1899例患者。术后1、3、6、12和24个月时,最大尿流率分别增至12.28 ml/s(95%CI:8.42 - 16.14)、12.88 ml/s(95%CI:9.85 - 15.92)、14.32 ml/s(95%CI:10.47 - 18.18)、14.93 ml/s(95%CI:10.19 - 19.67)和20.00 ml/s(95%CI:19.08 - 20.92)。国际前列腺症状评分分别降至-18.60(95%CI:-23.20 - -14.00)、-17.62(95%CI:-20.21 - -15.03)、-19.14(95%CI:-20.70 - -17.59)、-19.06(95%CI:-21.53 - -16.60)和-22.90(95%CI:-24.26 - -21.54)。生活质量分别降至-2.38(95%CI:-4.26 - -0.50)、-3.39(95%CI:-4.57 - -2.21)、-3.75(95%CI:-4.14 - -3.36)、-3.36(95%CI:-4.56 - -2.16)和-4.58(95%CI:-4.75 - -4.41)。残余尿量分别降至-231.16 ml(95%CI:-288.30 - -174.01)、-76.10 ml(95%CI:-116.71 - -35.50)、-159.90 ml(95%CI:-207.21 - -112.59)和-87.70 ml(95%CI:-91.91 - -83.48)。术后不良反应发生率均不高。经尿道双极等离子体前列腺切除术治疗中国高危及老年良性前列腺增生患者具有较好的临床疗效且无明显副作用。

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