四环素的光毒性：单线态δ-二氧的光敏发射
Phototoxicity of the tetracyclines: photosensitized emission of singlet delta dioxygen.
作者信息
Hasan T, Khan A U
出版信息
Proc Natl Acad Sci U S A. 1986 Jul;83(13):4604-6. doi: 10.1073/pnas.83.13.4604.
Abstract
The spectroscopic observation of 1268-nm emission of singlet oxygen photosensitized by tetracyclines in oxygenated solutions at room temperature is reported. In the series demeclocycline, tetracycline, and minocycline, the efficiency of singlet oxygen generation is found to parallel the clinical observation of relative frequency of phototoxicity of these antibiotics, suggesting singlet oxygen generation as the origin of their phototoxicity.
摘要
报道了在室温下对四环素在含氧溶液中光敏化产生的单线态氧的1268纳米发射进行的光谱观察。在去甲金霉素、四环素和米诺环素系列中，发现单线态氧的产生效率与这些抗生素光毒性相对频率的临床观察结果平行，这表明单线态氧的产生是它们光毒性的根源。
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