Department of Chemistry, The University Of Hull, Kingston-Upon-Hull, HU6 7RX, U.K.
Theranostics. 2012;2(9):916-66. doi: 10.7150/thno.4571. Epub 2012 Oct 4.
Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.
卟啉类分子在疾病治疗中有独特的治疗作用；它们已被用于成像、检测和治疗不同形式的病变组织，包括年龄相关性黄斑变性和多种不同类型的癌症。目前的重点是肿瘤组织的临床成像；光敏剂的靶向递送以及光敏剂在多模态生物医学治疗性纳米平台中的应用潜力。本文综述了卟啉类分子在成像和 PDT 中的作用，以及研究如何提高它们在病变组织中的选择性摄取及其在治疗性应用中的效用。
