The Ithree Institute, University of Technology Sydney, City Campus, Ultimo, NSW 2007, Australia; NSW Department of Primary Industries, Elizabeth Macarthur Agricultural Institute, Sydney, Australia.
The Ithree Institute, University of Technology Sydney, City Campus, Ultimo, NSW 2007, Australia.
Plasmid. 2019 Mar;102:56-61. doi: 10.1016/j.plasmid.2019.03.002. Epub 2019 Mar 15.
IncHI2-ST1 plasmids play an important role in co-mobilizing genes conferring resistance to critically important antibiotics and heavy metals. Here we present the identification and analysis of IncHI2-ST1 plasmid pSPRC-Echo1, isolated from an Enterobacter hormaechei strain from a Sydney hospital, which predates other multi-drug resistant IncHI2-ST1 plasmids reported from Australia. Our time-resolved phylogeny analysis indicates pSPRC-Echo1 represents a new lineage of IncHI2-ST1 plasmids and show how their diversification relates to the era of antibiotics.
IncHI2-ST1 质粒在共同转移赋予抗生素和重金属抗性的基因方面发挥着重要作用。在这里，我们介绍了从悉尼医院的肠杆菌属霍氏菌菌株中分离出的 IncHI2-ST1 质粒 pSPRC-Echo1 的鉴定和分析，该质粒早于澳大利亚报道的其他多药耐药 IncHI2-ST1 质粒。我们的时分辨支分析表明，pSPRC-Echo1 代表 IncHI2-ST1 质粒的一个新谱系，并展示了它们的多样化与抗生素时代的关系。
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