高通量基因多态性揭示多重耐药序列类型 3-IncHI2 质粒的遗传可塑性。
High Genetic Plasticity in Multidrug-Resistant Sequence Type 3-IncHI2 Plasmids Revealed by Sequence Comparison and Phylogenetic Analysis.
机构信息
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China.
Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China.
出版信息
Antimicrob Agents Chemother. 2018 Mar 27;62(4). doi: 10.1128/AAC.02068-17. Print 2018 Apr.
Abstract
We report a novel fusion plasmid, pP2-3T, cointegrating sequence type 3 (ST3)-IncHI2 with an IncFII plasmid backbone mediating multidrug resistance (MDR) and virulence. Phylogenetic analysis and comparative genomics revealed that pP2-3T and other MDR ST3-IncHI2 plasmids clustered together, representing a unique IncHI2 lineage that exhibited high conservation in backbones of plasmids but possessed highly genetic plasticity in various regions by acquiring numerous antibiotic resistance genes and fusing with other plasmids. Surveillance studies should be performed to monitor multiresistance IncHI2 plasmids among .
摘要
我们报告了一种新型融合质粒 pP2-3T，其同时带有序列型 3（ST3）-IncHI2 以及介导多药耐药（MDR）和毒力的 IncFII 质粒骨架。系统发育分析和比较基因组学显示，pP2-3T 和其他 MDR ST3-IncHI2 质粒聚集在一起，代表了一个独特的 IncHI2 谱系，该谱系在质粒的骨架中高度保守，但通过获得众多抗生素耐药基因并与其他质粒融合，在各个区域表现出高度的遗传可塑性。应进行监测研究，以监测. 中多耐药 IncHI2 质粒。
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