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鸽子对吗啡作用产生耐受性，但对可乐定作用在按计划控制行为方面不存在交叉耐受性。

Tolerance to effects of morphine without cross tolerance to effects of clonidine on schedule-controlled behavior of pigeons.

作者信息

Katz J L

出版信息

Psychopharmacology (Berl). 1986;89(3):323-6. doi: 10.1007/BF00174368.

DOI:10.1007/BF00174368
PMID:3088657
Abstract

Schedule-controlled responding was maintained under a multiple fixed-interval, fixed-ratio schedule in pigeons. Dose-related decreases in response rates were produced by clonidine (0.001-0.1 mg/kg) and morphine (0.3-5.6 mg/kg). Chronic administration of morphine produced (1) tolerance to effects of morphine, as evidenced by a decrease in potency of morphine and (2) sensitivity to opioid antagonists, as evidenced by an increase in potency of naloxone. Dose-effect curves for clonidine were not appreciably altered by chronic morphine administration.

摘要

在鸽子中，按多重固定间隔、固定比率时间表维持定时控制反应。可乐定（0.001 - 0.1毫克/千克）和吗啡（0.3 - 5.6毫克/千克）产生与剂量相关的反应率降低。长期给予吗啡产生了（1）对吗啡作用的耐受性，表现为吗啡效力降低，以及（2）对阿片类拮抗剂的敏感性，表现为纳洛酮效力增加。长期给予吗啡并未明显改变可乐定的剂量 - 效应曲线。

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本文引用的文献

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Behavioral effects of some psychopharmacological agents.一些精神药理药物的行为效应。
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Clonidine analgesia and suppression of operant responding: dissociation of mechanism.可乐定镇痛与操作性反应抑制：机制的分离
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Effects of clonidine and some alpha-adrenergic antagonists alone and in combination on schedule-controlled behavior in pigeons and mice.可乐定和某些α-肾上腺素能拮抗剂单独及联合使用对鸽子和小鼠按程序控制行为的影响。
Psychopharmacology (Berl). 1984;83(1):38-43. doi: 10.1007/BF00427419.
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Behavioural and biochemical effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (St 155) on the central nervous system.2-（2,6-二氯苯基氨基）-2-咪唑啉盐酸盐（St 155）对中枢神经系统的行为和生化影响。
Br J Pharmacol. 1969 Feb;35(2):253-64. doi: 10.1111/j.1476-5381.1969.tb07984.x.
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J Pharmacol Exp Ther. 1976 Mar;196(3):625-36.