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Behavioral influences on tolerance to the effects of morphine on schedule-controlled behavior.

作者信息

Smith J B

出版信息

Psychopharmacology (Berl). 1979;66(1):105-7. doi: 10.1007/BF00431998.

DOI:10.1007/BF00431998
PMID:120535
Abstract

Responding of pigeons was maintained under a multiple fixed interval, fixed ratio schedule of food delivery, and 10 mg/kg morphine was administered daily. Responding during both schedule components was initially decreased and measurable tolerance developed to this effect after four daily injections. However, the rate of tolerance development differed depending on whether or not presence of the drug coincided with performance during experimental sessions. Tolerance developed more rapidly when morphine was given before daily experimental sessions than when morphine was given daily but animals did not perform daily in experimental sessions. Tolerance to the rate-decreasing effects of morphine depended on relations between presence of the drug and exposure to experimental sessions.

摘要

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本文引用的文献

1
Behavioral variables affecting the development of amphetamine tolerance.影响苯丙胺耐受性发展的行为变量。
Psychopharmacologia. 1966;9(2):170-82. doi: 10.1007/BF00404721.
2
Performance influence on the development of tolerance to amphetamine.
Pharmacol Biochem Behav. 1973 Nov-Dec;1(6):703-8. doi: 10.1016/0091-3057(73)90034-8.
3
An investigation of pharmacologic and behavioral tolerance to morphine in rats.
J Pharmacol Exp Ther. 1973 May;185(2):300-6.
4
Psychopharmacology (Berl). 1987;92(3):327-33. doi: 10.1007/BF00210839.
4
Situational specificity of tolerance to effects of phencyclidine on responding of rats under fixed-ratio and spaced-responding schedules.苯环利定对大鼠在固定比率和间隔反应程序下反应的耐受性的情境特异性。
Psychopharmacology (Berl). 1991;103(1):121-8. doi: 10.1007/BF02244086.
5
Situational specificity of tolerance to decreased operant responding by morphine and l-nantradol.
Psychopharmacology (Berl). 1991;103(1):115-20. doi: 10.1007/BF02244085.
Chronic delta-9-tetrahydrocannabinol. Transient and lasting effects on avoidance behavior.
慢性 Δ9-四氢大麻酚。对回避行为的短暂和持久影响。
Pharmacol Biochem Behav. 1976 Jan;4(1):17-21. doi: 10.1016/0091-3057(76)90169-6.
5
The existence of tolerance to and cross-tolerance between d-amphetamine and methylphenidate for their effects on milk consumption and on differential-reinforcement-of-low-rate performance in the rat.右旋苯丙胺和哌醋甲酯对大鼠乳汁消耗及低速率行为差异强化表现的影响存在耐受性及交叉耐受性。
J Pharmacol Exp Ther. 1976 Sep;198(3):635-47.
6
Pharmacological and behavioral components of tolerance to LSD and mescaline in rats.大鼠对麦角酸二乙酰胺（LSD）和三甲氧苯乙胺（mescaline）耐受性的药理学和行为学成分
Pharmacol Biochem Behav. 1977 Sep;7(3):239-44. doi: 10.1016/0091-3057(77)90140-x.
7
The role of reinforcement loss in tolerance to chronic delta9-tetrahydrocannabinol effects on operant behavior of rhesus monkeys.强化损失在恒河猴对慢性 Δ9-四氢大麻酚对操作性行为影响的耐受性中的作用。
Pharmacol Biochem Behav. 1976 Aug;5(2):123-8. doi: 10.1016/0091-3057(76)90026-5.