埃及一家大学医院关于β-内酰胺类抗生素诱导的万古霉素耐药性的报告。
Report of β-lactam antibiotic-induced vancomycin-resistant from a university hospital in Egypt.
作者信息
Taha A E, Badr M F, El-Morsy F E, Hammad E
机构信息
Microbiology and Immunology Unit, Department of Pathology, College of Medicine, Jouf University, Al-Jouf, Saudi Arabia.
Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
出版信息
New Microbes New Infect. 2019 Jan 30;29:100507. doi: 10.1016/j.nmni.2019.01.003. eCollection 2019 May.
We report a case of hospital-acquired pneumonia that to our knowledge is the first description in Egypt of the emergence of vancomycin (VA)-resistant due to the concomitant use of β-lactams. The combination of β-lactam antibiotics and VA in the treatment of methicillin-resistant must be avoided to refrain from inducing VA resistance; further, if there is coinfection with Gram-negative bacilli, β-lactams must be avoided. If β-lactam antibiotic-induced VA-resistant methicillin-resistant is isolated, then β-lactams must be avoided until the organism's sensitivity to VA is restored if VA is the only therapeutic option available.
我们报告了一例医院获得性肺炎病例，据我们所知，这是埃及首例因同时使用β-内酰胺类药物而出现耐万古霉素（VA）的病例描述。在治疗耐甲氧西林菌时，必须避免β-内酰胺类抗生素与VA联合使用，以免诱导产生VA耐药性；此外，如果存在革兰氏阴性杆菌合并感染，必须避免使用β-内酰胺类药物。如果分离出β-内酰胺类抗生素诱导的耐VA耐甲氧西林菌，且VA是唯一可用的治疗选择，那么在该菌株对VA的敏感性恢复之前，必须避免使用β-内酰胺类药物。
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