UQ Genomics Initiative, The University of Queensland, St. Lucia, QLD, 4072, Australia.
School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, 2006, Australia.
Commun Biol. 2019 Mar 13;2:99. doi: 10.1038/s42003-019-0342-5. eCollection 2019.
The Tasmanian devil () is threatened by a contagious cancer, known as Devil Facial Tumour Disease (DFTD). A highly diverse T-cell receptor (TCR) repertoire is crucial for successful host defence against cancers. By investigating TCR beta chain diversity in devils of different ages, we show that the T-cell repertoire in devils constricts in their second year of life, which may explain the higher DFTD prevalence in older devils. Unexpectedly, we also observed a pronounced decline in TCR diversity and T cell clonal expansion in devils after DFTD infection. These findings overturned the previous assumption that DFTD did not directly impact host immunity.
袋獾（）受到一种传染性癌症的威胁，这种癌症被称为袋獾面部肿瘤疾病（DFTD）。高度多样化的 T 细胞受体（TCR）库对于成功抵御癌症的宿主防御至关重要。通过研究不同年龄袋獾的 TCRβ链多样性，我们发现袋獾的 T 细胞库在其生命的第二年就会收缩，这可能解释了为什么老年袋獾中 DFTD 的患病率更高。出乎意料的是，我们还观察到袋獾在感染 DFTD 后 TCR 多样性和 T 细胞克隆扩增明显下降。这些发现推翻了之前认为 DFTD 不会直接影响宿主免疫的假设。
Zotero 插件
