Brenner U, Müller J M, Walter M, Holzmüller W, Keller H W
Zentralbl Chir. 1986;111(9):526-35.
72 patients with gastro-intestinal carcinomas were involved in a retrospective study in which 97 metabolic parameters were pre-operatively determined from each of them and subsequently tested by stepwise discriminant analysis for their bearings on clinical mortality. A discriminant function of seven parameters was obtained and can be used as a prognostic nutritional index for successful subdivision of patients into differentiated risk groups. Two prospective control studies were conducted into 605 patients consecutively operated on for benign and malignant diseases for the purpose of testing the nutritional index for its prognostic information potential. The discriminant function proved to be applicable to differentiation between patients with high, moderate, and low surgical risk. Findings were unambiguous. The nutritional index can thus be used as an aid for decision-making in cases in which alternatives exist between several surgical approaches. The importance of malnutrition as a possible causative factor of complications is likely to grow along with the invasiveness of the intervention.
72例胃肠癌患者参与了一项回顾性研究,术前测定了其中每例患者的97项代谢参数,随后通过逐步判别分析测试这些参数对临床死亡率的影响。获得了一个由七个参数组成的判别函数,可作为一种预后营养指标,用于将患者成功细分为不同风险组。针对605例因良性和恶性疾病而连续接受手术的患者进行了两项前瞻性对照研究,以测试该营养指标的预后信息潜力。判别函数被证明适用于区分高、中、低手术风险的患者。结果明确。因此,在存在多种手术方式可供选择的情况下,该营养指标可作为决策辅助工具。随着干预措施的侵入性增加,营养不良作为并发症可能的致病因素的重要性可能会上升。