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免疫淋巴细胞转移后未致敏受体中抗体反应的动力学

Kinetics of antibody response in unprimed recipients after transfer of immune lymphocytes.

作者信息

Varesio L, Landolfo S, Cavallo G

出版信息

Folia Biol (Praha). 1978;24(4):264-9.

PMID:308888
Abstract

Spleen cells from mice immunized with SRBC were transferred, at various times after immunization, to non-irradiated and lethally irradiated syngeneic recipients. The PFC kinetics and anti-SRBC antibody titres were followed in various groups of mice. Similar results were obtained both in non-irradiated and lethally irradiated recipients, showing that after the transfer: a) PFC proliferation was blocked, b) PFC blocking was unrelated to their maturation stage, c) resting PFC were still able to synthesize antibodies, d) blocking activity was radio-resistant.

摘要

用绵羊红细胞(SRBC)免疫的小鼠脾脏细胞,在免疫后的不同时间,被转移到未受照射和受到致死剂量照射的同基因受体小鼠体内。对不同组小鼠的空斑形成细胞(PFC)动力学和抗SRBC抗体滴度进行了跟踪观察。在未受照射和受到致死剂量照射的受体小鼠中均得到了相似的结果,表明在细胞转移后:a)PFC增殖受到阻断;b)PFC阻断与其成熟阶段无关;c)静止的PFC仍能够合成抗体;d)阻断活性具有抗辐射性。

相似文献

1
Kinetics of antibody response in unprimed recipients after transfer of immune lymphocytes.免疫淋巴细胞转移后未致敏受体中抗体反应的动力学
Folia Biol (Praha). 1978;24(4):264-9.
2
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T cell activation and cellular cooperation in autoimmune NZB/NZW F hybrid mice.自身免疫性NZB/NZW F1杂交小鼠中的T细胞活化与细胞协作
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Ontogeny of B-lymphocyte function. IX. Difference in the time of maturation of the capacity of B lymphocytes from foetal and neonatal mice to produce a heterogeneous antibody response to thymic-dependent and thymic-independent antigens.B淋巴细胞功能的个体发生。IX. 胎鼠和新生鼠B淋巴细胞对胸腺依赖性和胸腺非依赖性抗原产生异质性抗体反应能力的成熟时间差异。
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