Department of Orthopedics, Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian, Liaoning, China; Postdoctoral Workstation, Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian, Liaoning, China; First Hospital and Institute of Immunology, Jilin University, Changchun, Jilin, China.
Department of Orthopedics, Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian, Liaoning, China; Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Linggong Road, Dalian, China.
Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:1123-1132. doi: 10.1016/j.msec.2019.02.072. Epub 2019 Feb 19.
Osteonecrosis of the femoral head (ONFH) results in collapse of the femoral head and rapid destruction of the hip joint. The repair of post-collapse articular cartilage and subchondral bone is challenging. We interrupted the blood supply to the femoral head and established a full-thickness articular defect animal model after ONFH was determined via X-ray. Porous tantalum and a Bio-Gide collagen membrane, co-cultured with bone marrow mesenchymal stem cells (BMSCs) in vitro, were implanted into the defect zone to repair the full-thickness articular defect. Hyaline cartilage was detected on top of the tantalum near the edge of the defect 12 weeks post-operatively. Porous tantalum and a Bio-Gide collagen membrane with BMSCs may repair full-thickness articular defects if the blood supply can be reconstructed in the post-collapse stage of ONFH.
股骨头坏死（ONFH）导致股骨头塌陷和髋关节快速破坏。塌陷后关节软骨和软骨下骨的修复具有挑战性。我们通过 X 射线确定 ONFH 后，中断了股骨头的血液供应，并建立了全层关节缺损动物模型。将多孔钽和体外共培养的骨髓间充质干细胞（BMSCs）的 Bio-Gide 胶原膜植入缺损区，以修复全层关节缺损。术后 12 周，在缺损边缘附近的钽上检测到透明软骨。如果在 ONFH 塌陷后期能够重建血供，多孔钽和含有 BMSCs 的 Bio-Gide 胶原膜可能修复全层关节缺损。
