Vaughn C B, Chapman J, Garland M, Pederson B, Demitrish M M, Chinn B, Ward D, Enochs K, Groshko G, Rocchio R
Am J Clin Oncol. 1986 Jun;9(3):196-9. doi: 10.1097/00000421-198606000-00005.
Sixty-six patients with advanced colorectal cancer were treated with 5-fluorouracil, Mitomycin C, and 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. Fifty-seven patients were evaluable by completing 2 months of therapy. Nine patients (16.0%) achieved a complete remission (CR) with the above combination. A partial remission (PR) was seen in 9 patients. The response rate (CR + PR) was 32%. The average duration of response was 8.5 months. Mucositis, leukopenia, and thrombocytopenia were the significant toxicities experienced in this study.
