5-氟尿嘧啶、甲基环己亚硝脲和柔红霉素用于结直肠癌的II期研究：一项癌症与白血病B组研究
Phase II study of 5-fluorouracil, methyl-CCNU, and daunorubicin in colorectal cancer: a Cancer and Leukemia Group B study.
作者信息
White L A, Perry M C, Kardinal C G, Kennedy B J, Weiss R B, Carey R W
出版信息
Cancer Treat Rep. 1979 Feb;63(2):215-7.
PMID:445497
Abstract
The three-drug combination of 5-fluorouracil, methyl-CCNU, and daunorubicin was evaluated in 38 patients with unresectable or metastatic carcinoma of the colon. There were five partial responses and one complete response for an overall response rate of 16%. Although toxicity was tolerable, daunorubicin failed to add to the 5-fluorouracil and methyl-CCNU combination.
摘要
对38例无法切除或转移性结肠癌患者评估了5-氟尿嘧啶、甲基环己亚硝脲和柔红霉素的三联药物组合。有5例部分缓解和1例完全缓解，总缓解率为16%。虽然毒性可耐受，但柔红霉素并未增强5-氟尿嘧啶和甲基环己亚硝脲组合的疗效。
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