老挝人民民主共和国引入含腮腺炎疫苗之前腮腺炎的血清流行率：一项基于全国横断面人群调查的结果
Seroprevalence of mumps before the introduction of mumps-containing vaccine in Lao PDR: results from a nationwide cross-sectional population-based survey.
作者信息
Okabayashi Hironori, Komada Kenichi, Kidokoro Minoru, Kitamura Tomomi, Miyano Shinsuke, Ito Tomoo, Phounphenghak Kongxay, Pathammavong Chansay, Murano Keiko, Nagai Misato, Mori Yoshio, Komase Katsuhiro, Xeuatvongsa Anonh, Takeda Makoto, Hachiya Masahiko
机构信息
Bureau of International Health Cooperation, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan.
Department of Virology 3, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan.
出版信息
BMC Res Notes. 2019 Mar 19;12(1):155. doi: 10.1186/s13104-019-4194-3.
OBJECTIVE
Mumps-containing vaccine is currently not a component of the national immunization schedule in Lao People's Democratic Republic (PDR). Mumps itself is not a notifiable disease in the country and the seroprevalence of anti-mumps immunoglobulin G (IgG) in the general population is unknown. In this study, anti-mumps IgG was measured in 2058 blood samples to evaluate population immunity in the country.
RESULTS
The seroprevalence of anti-mumps IgG showed a gradual increase with increasing age, starting at 10.6% (95% CI 7.4-13.7) in participants aged 1-2 years, and almost plateaued at about 75% in individuals older than 11-12 years, though it still tended toward a small increase up to 89.6% (95% CI 86.6-92.6) in participants aged 40 years or older. Compared with the results of previous studies, this increase with increasing age is less marked and the plateau of anti-mumps seroprevalence is lower. We attribute this result mainly to the lower population density in Lao PDR.
目的
含腮腺炎疫苗目前并非老挝人民民主共和国国家免疫规划的组成部分。在该国，腮腺炎本身并非法定报告疾病，普通人群中抗腮腺炎免疫球蛋白G（IgG）的血清流行率尚不清楚。在本研究中，对2058份血样进行了抗腮腺炎IgG检测，以评估该国的人群免疫力。
结果
抗腮腺炎IgG的血清流行率随年龄增长呈逐渐上升趋势，1至2岁参与者中起始血清流行率为10.6%（95%置信区间7.4 - 13.7），11至12岁以上个体中血清流行率几乎稳定在约75%，不过在40岁及以上参与者中仍有小幅上升趋势，最高达89.6%（95%置信区间86.6 - 92.6）。与先前研究结果相比，这种随年龄增长的上升幅度较小，抗腮腺炎血清流行率的稳定水平较低。我们将这一结果主要归因于老挝人民民主共和国较低的人口密度。
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