LaoLuxLab, Institut Pasteur du Lao PDR, Vientiane, Lao PDR; Institute of Immunology, Centre de Recherche Public de la Santé/Laboratoire National de Santé, Luxembourg City, Luxembourg.
Clin Microbiol Infect. 2014 Oct;20(10):O664-71. doi: 10.1111/1469-0691.12586. Epub 2014 Mar 6.
In the Lao People's Democratic Republic (PDR), mumps is not a notifiable disease and mumps vaccine is currently not included in the routine childhood immunization programme. In order to assess the burden of disease, we investigated the seroprevalence of mumps-specific IgG antibodies across four provinces. In addition, we genetically characterized mumps viruses from the past 3 years from several outbreaks and single cases. Blood and/or throat swabs from suspected cases were investigated for specific IgM antibodies or viral RNA. Mumps cases occurred between March and November in 2011-2013 and 5- to 15-year-olds were most affected. Four sequences from an outbreak in the north of Lao PDR in 2011 were identical and belonged to genotype G. Eight sequences from two outbreaks and two individual cases from 2012 and 2013 belonged to genotype J. In addition, sera collected from 2379 healthy infants and school pupils aged between 9 months and 19 years and from pregnant women aged between 16 and 46 years were investigated for mumps-specific IgG. Overall, 58.2% were positive, 39.5% were negative and the remaining 2.3% were equivocal. The seropositivity increased with age, with the lowest percentage found in <1-year-old infants (9.1%) and the highest in the cohort of pregnant women (69.2%). More female subjects than male subjects were seropositive (60.4 vs. 54.9%). There were some differences between the locations. Mumps should be a notifiable disease in Lao PDR in order to get more accurate case numbers and cost estimates for public health-care, and vaccination of children and high-risk groups should be considered.
在老挝人民民主共和国（老挝），流行性腮腺炎不是法定报告疾病，流行性腮腺炎疫苗目前也未纳入常规儿童免疫规划。为评估疾病负担，我们对四个省的流行性腮腺炎特异性 IgG 抗体血清流行率进行了调查。此外，我们还对过去 3 年来自几次暴发和单个病例的流行性腮腺炎病毒进行了基因特征分析。采集疑似病例的血液和/或咽拭子，检测特异性 IgM 抗体或病毒 RNA。2011-2013 年，流行性腮腺炎病例发生于 3 月至 11 月，5-15 岁人群受影响最大。2011 年老挝北部一次暴发的 4 个序列完全相同，属于基因型 G。2012 年和 2013 年两次暴发和两例散发病例的 8 个序列属于基因型 J。此外，还对 2379 名 9 个月至 19 岁的健康婴儿和学童以及 16-46 岁的孕妇血清进行了流行性腮腺炎特异性 IgG 检测。总体来看，58.2%为阳性，39.5%为阴性，其余 2.3%为不确定。血清阳性率随年龄增长而增加，<1 岁婴儿的阳性率最低（9.1%），孕妇的阳性率最高（69.2%）。女性血清阳性率高于男性（60.4% vs. 54.9%）。不同地区存在一定差异。老挝应将流行性腮腺炎作为法定报告疾病，以便更准确地统计病例数和估算公共卫生保健费用，还应考虑对儿童和高危人群进行疫苗接种。
