Cooppan R M, Schutte C H, Mayet F G, Dingle C E, Van Deventer J M, Mosese P G
Am J Trop Med Hyg. 1986 Jul;35(4):765-76. doi: 10.4269/ajtmh.1986.35.765.
Morbidity from urinary schistosomiasis was assessed on clinical, radiological, parasitologic and biochemical evidence in 510 schoolchildren living in a Schistosoma haematobium endemic area. The results were viewed against the background of the prevalence and intensity of infection in the subjects. Clinical morbidity correlated well with the intensity of infection, the latter in turn being influenced by factors such as water contact pattern, sex and water source. A surprisingly high prevalence (42%) of abnormalities was observed in the urinary tract of subjects, but no relationship could be demonstrated between the intensity of infection and structural damage to the urinary tract. Urographic changes were more severe in the 11-15 year age group than in the 6-10 year group. Significant rectal involvement (76%) in S. haematobium-infected subjects was regarded as a reflection of the heavy worm burdens borne by these children. The morbidity described in this study indicates a definite degree of pathology in the infected children but the impression was that they suffered only mild disability. However, given the structural lesions seen on urography and the limited sensitivity of the biochemical tests used for the assessment of renal function, renal pathology cannot be ruled out. Further studies on the renal status of these subjects are essential.
根据临床、放射学、寄生虫学和生物化学证据，对生活在埃及血吸虫流行地区的510名学童的泌尿血吸虫病发病率进行了评估。研究结果结合了这些受试者的感染率和感染强度。临床发病率与感染强度密切相关，而感染强度又受诸如接触水的方式、性别和水源等因素的影响。在受试者的尿路中观察到异常的发生率出奇地高（42%），但未发现感染强度与尿路结构损伤之间存在关联。尿路造影变化在11至15岁年龄组比6至10岁年龄组更为严重。埃及血吸虫感染受试者直肠受累显著（76%），这被认为反映了这些儿童体内沉重的虫负荷。本研究中描述的发病率表明受感染儿童存在一定程度的病理状况，但给人的印象是他们仅患有轻度残疾。然而，鉴于尿路造影显示的结构病变以及用于评估肾功能的生化检测的有限敏感性，不能排除肾脏病理状况。对这些受试者的肾脏状况进行进一步研究至关重要。
