Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg (FAU) and Universitaetsklinikum Erlangen, Erlangen, Germany.
Institute of Medical Physics (IMP), Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Osteoarthritis Cartilage. 2019 Jul;27(7):1043-1047. doi: 10.1016/j.joca.2019.01.019. Epub 2019 Mar 16.
To analyze the age-related changes of the physiological hand joint architecture.
To address this concept, healthy individuals (each 10 women and 10 men in six different age decades spanning from 21 to 80 years) were recruited through a field campaign, investigated for the absence of rheumatic diseases and other comorbidities and received high-resolution quantitative computed tomography (HR-pQCT) examination of the hand joints. Number and extent of erosions and osteophytes were quantified across the ages and different sexes.
Bone erosions [median (Q1-Q3), 1 (0-2)] and osteophytes [2 (1-4)] were found in healthy women and men with no significant sex differences. Structural changes however accumulated with age: the overall incidence rate ratio (IRR) for the number of erosions and osteophytes per age were 1.04 (95% CI: erosions 1.03-1.06; osteophytes: 1.03-1.05). This means a 4% increase in the number of erosions and osteophytes per year. Using third decade as reference, healthy individuals in the age decades from 50 years had higher IRR for erosion numbers (sixth, seventh, eigth decade: 4.87 (2.20-11.75), 6.81 (3.08-16.46) and 6.92 (3.11-16.79)) compared to younger subjects (fourth, fifth decade: 1.80 (0.69-4.87), 1.53 (0.59-4.10)). The IRRs of osteophytes also indicate a gradual increase after the fifth decade, with IRRs of 2.32 (1.32-4.17), 4.17 (2.38-7.49) and 6.86 (3.97-12.20) for the sixth, seventh and eigth decades, respectively.
Structural changes in the hand joints of healthy individuals are age dependent. While being rare under 50 years of age, erosions and osteophytes accumulate above the age of 50, suggesting that the threshold between "normal" and "pathological" is shifted with the increase of age.
分析生理手部关节结构的年龄相关性变化。
为了解决这个概念，通过实地调查招募了健康个体（每个年龄段有 10 名女性和 10 名男性，跨越 21 至 80 岁的 6 个不同年龄段），调查他们是否患有风湿性疾病和其他合并症，并接受手部关节的高分辨率定量计算机断层扫描（HR-pQCT）检查。在不同年龄段和不同性别之间量化了侵蚀和骨赘的数量和程度。
在健康的女性和男性中发现了骨侵蚀[中位数（Q1-Q3），1（0-2）]和骨赘[2（1-4）]，且无明显性别差异。然而，结构变化会随着年龄的增长而积累：侵蚀和骨赘数量的总发生率比值（IRR）为每个年龄的 1.04（95%置信区间：侵蚀 1.03-1.06；骨赘：1.03-1.05）。这意味着每年侵蚀和骨赘的数量增加 4%。以第三个十年为参考，50 岁以上年龄组的健康个体，侵蚀数量的 IRR 更高（第六、七、八十年：4.87（2.20-11.75）、6.81（3.08-16.46）和 6.92（3.11-16.79））与年轻受试者相比（第四、五十年：1.80（0.69-4.87）、1.53（0.59-4.10））。骨赘的 IRR 也表明，第五十年后逐渐增加，第六、七、八十年的 IRR 分别为 2.32（1.32-4.17）、4.17（2.38-7.49）和 6.86（3.97-12.20）。
健康个体手部关节的结构变化与年龄有关。虽然在 50 岁以下很少见，但侵蚀和骨赘在 50 岁以上积累，这表明“正常”和“病理性”之间的阈值随着年龄的增长而变化。
