Mostafa S M, Lockhart A, Kumar D, Bayoumi M
Anaesthesia. 1986 May;41(5):493-8. doi: 10.1111/j.1365-2044.1986.tb13273.x.
The effects of fentanyl and alfentanil on intra-ocular pressure during anaesthesia were investigated in 50 consecutive patients in a double-blind controlled trial. Both drugs produced a significant reduction in intraocular pressure (p less than 0.01). Alfentanil produced significantly greater reduction (48.5 percent) than fentanyl (28.6 percent) (p less than 0.01). A small but statistically significant reduction in arterial pressure (15 percent approximately) and heart rate (18 percent approximately), were observed with both agents, but no significant differences between them were noted. It is suggested that alfentanil may be a suitable alternative to fentanyl in ophthalmic anaesthesia.
在一项双盲对照试验中，对50例连续患者研究了芬太尼和阿芬太尼在麻醉期间对眼压的影响。两种药物均使眼压显著降低（p<0.01）。阿芬太尼产生的降低幅度（48.5%）明显大于芬太尼（28.6%）（p<0.01）。两种药物均观察到动脉压有小幅度但具有统计学意义的降低（约15%）和心率降低（约18%），但两者之间未发现显著差异。提示在眼科麻醉中，阿芬太尼可能是芬太尼的合适替代药物。
