Liberman H, Pybus D A, Torda T A
Anaesth Intensive Care. 1985 Feb;13(1):5-11. doi: 10.1177/0310057X8501300101.
Alfentanil and fentanyl were compared as supplements to thiopentone, nitrous oxide, relaxant anaesthesia in a randomised, double blind trial carried out on 55 adult patients undergoing elective surgery. The fentanyl-treated patients resumed spontaneous ventilation more rapidly at the end of anaesthesia (3 minutes) than the alfentanil-treated group (5.1 minutes, p less than 0.02). In other respects the drugs appeared indistinguishable. A computer model is used to explain why, despite the shorter elimination half-life, the alfentanil-treated patients did not awaken more rapidly than those in the fentanyl group.
在一项对55例接受择期手术的成年患者进行的随机双盲试验中，比较了阿芬太尼和芬太尼作为硫喷妥钠、氧化亚氮、肌肉松弛剂麻醉辅助用药的效果。与阿芬太尼治疗组（5.1分钟，p<0.02）相比，芬太尼治疗组患者在麻醉结束时（3分钟）恢复自主通气更快。在其他方面，这两种药物似乎没有差异。使用计算机模型来解释为什么尽管阿芬太尼的消除半衰期较短，但阿芬太尼治疗组患者的苏醒速度并不比芬太尼组更快。
