载脂蛋白E e4等位基因与轻度阿尔茨海默病社区居住个体海马磁共振成像体积之间的关系。
The relationship between the apolipoprotein E e4 allele and hippocampal magnetic resonance imaging volume in community-dwelling individuals with mild Alzheimer's disease.
作者信息
Walsh Bernard, Slater Stuart, Nair Balakrishnan, Attia John
机构信息
Department of Geriatric Medicine, John Hunter Hospital, Newcastle, Australia,
Hunter Imaging Group, Cardiff, Australia.
出版信息
Degener Neurol Neuromuscul Dis. 2013 Mar 2;3:11-14. doi: 10.2147/DNND.S40835. eCollection 2013.
BACKGROUND
The degree of hippocampal magnetic resonance imaging (MRI) volume loss in Alzheimer's disease (AD) is commonly accepted as a marker of disease severity, yet remains expensive, unavailable, or not tolerated by many patients.
AIM
To examine whether the presence of one or more apolipoprotein E (ApoE) e4 alleles is associated with smaller hippocampal MRI volumes in a population of early AD patients.
METHODS
A total of 88 consecutive patients attending a community-based memory disorders clinic who had both mild dementia on the Clinical Dementia Rating scale and criteria for probable AD were recruited. We examined the relationship between ApoE e4 allele load and hippocampal atrophy on MRI volumes.
RESULTS
There was no association between the ApoE e4 load and hippocampal volume in this cohort.
CONCLUSION
This study suggests that the presence of one or more ApoE e4 alleles cannot be used to estimate pathological disease load in early AD.
背景
阿尔茨海默病（AD）中海马磁共振成像（MRI）体积减少的程度通常被认为是疾病严重程度的一个指标，但它仍然昂贵，许多患者无法进行该项检查或不耐受。
目的
在早期AD患者群体中，研究一个或多个载脂蛋白E（ApoE）e4等位基因的存在是否与较小的海马MRI体积相关。
方法
连续招募了88名在社区记忆障碍诊所就诊的患者，这些患者在临床痴呆评定量表上均有轻度痴呆且符合可能的AD标准。我们研究了ApoE e4等位基因负荷与MRI体积上的海马萎缩之间的关系。
结果
在该队列中，ApoE e4负荷与海马体积之间没有关联。
结论
本研究表明，一个或多个ApoE e4等位基因的存在不能用于估计早期AD的病理疾病负荷。
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