Falomir-Lockhart Eugenia, Dolcetti Franco Juan Cruz, García-Segura Luis Miguel, Hereñú Claudia Beatriz, Bellini Maria Jose
Laboratorio de Bioquimica del Envejecimiento, Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Facultad de Ciencias Médicas, UNLP-CONICET, La Plata, Argentina.
Instituto Cajal, CSIC, Madrid, Spain.
Front Aging Neurosci. 2019 Mar 5;11:48. doi: 10.3389/fnagi.2019.00048. eCollection 2019.
Microglial cells become dystrophic with aging; this phenotypic alteration contributes to basal central nervous system (CNS) neuroinflammation being a risk factor for age related neurodegenerative diseases. In previous studies we have observed that insulin like growth factor 1 (IGF1) gene therapy is a feasible approach to target brain cells, and that is effective to modify inflammatory response and to ameliorate cognitive or motor deficits . Based on these findings, the main aim of the present study is to investigate the effect of IGF1 gene therapy on microglia distribution and morphology in the senile rat. We found that IGF1 therapy leads to a region-specific modification of aged microglia population.
小胶质细胞会随着衰老而发生营养不良；这种表型改变会导致中枢神经系统（CNS）基础神经炎症，而这是与年龄相关的神经退行性疾病的一个风险因素。在之前的研究中，我们观察到胰岛素样生长因子1（IGF1）基因疗法是一种针对脑细胞的可行方法，并且它能有效改变炎症反应并改善认知或运动缺陷。基于这些发现，本研究的主要目的是探讨IGF1基因疗法对老年大鼠小胶质细胞分布和形态的影响。我们发现IGF1疗法会导致老年小胶质细胞群体的区域特异性改变。
