Egorov N S, Baranova I P, Kozlova Iu I, Maksimov V N, Polin A N
Antibiot Med Biotekhnol. 1986 May;31(5):337-41.
The methods of mathematical desing of experiments such as Box and full factorial design were used in the study. As a result a three-component medium including 1-2 per cent of mollases, 10-20 mg% of yeast autolysate and 1-2 per cent of KH2PO4 was recommended for biosynthesis of nisin.
该研究采用了诸如Box法和全因子设计等实验的数学设计方法。结果推荐了一种用于乳酸链球菌素生物合成的三元培养基，其包含1-2%的糖蜜、10-20mg%的酵母自溶物和1-2%的磷酸二氢钾。
