Kozlova Iu I, Grushina V A, Baranova I P, Egorov N S
Mikrobiologiia. 1990 Jul-Aug;59(4):704-7.
Nisin synthesis by Streptococcus lactis, strain MGU, grown as a combined culture together with Proteus vulgaris and Bacillus mesentericus under stationary conditions or with stirring does not depend on the quantity of inoculated associated cells. Nisin synthesis in the combined culture drops down by 10-20% at the initial pH 7.5 of the growth medium which is unfavourable for S. lactis producing nisin. The level of nisin biosynthesis does not rise when the pH of the medium is adjusted (either naturally or artificially) to 6.6-6.8 in the presence of glucose and yeast autolysate. S. lactis inhibits the growth of B. mesentericus when grown together with it whereas P. vulgaris inhibits the growth of S. lactis in their combined culture.
乳酸链球菌MGU菌株在静止条件下或搅拌条件下与普通变形杆菌和肠系膜芽孢杆菌共同培养时合成乳酸链球菌素，这并不取决于接种的相关细胞数量。在不利于产生乳酸链球菌素的乳酸链球菌生长的初始pH 7.5的生长培养基中，混合培养物中乳酸链球菌素的合成下降10%-20%。在葡萄糖和酵母自溶物存在的情况下，将培养基的pH值自然或人工调节至6.6-6.8时，乳酸链球菌素的生物合成水平不会提高。乳酸链球菌与肠系膜芽孢杆菌共同培养时会抑制其生长，而在混合培养中普通变形杆菌会抑制乳酸链球菌的生长。
