猪圆环病毒2型感染的小鼠模型
Mouse models of porcine circovirus 2 infection.
作者信息
Ouyang Ting, Liu Xiao-Hui, Ouyang Hong-Sheng, Ren Lin-Zhu
机构信息
Science and Technology Innovation Center for Animal Genome Editing of Jilin Province College of Animal Sciences Jilin University Changchun Jilin China.
出版信息
Animal Model Exp Med. 2018 Apr 19;1(1):23-28. doi: 10.1002/ame2.12009. eCollection 2018 Mar.
Abstract
PCV2 is considered the main pathogen of porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD). However, the exact mechanism underlying PCVD/PCVAD is currently unknown. Mouse models of PCV2 are valuable experimental tools that can shed light on the pathogenesis of infection and will enable the evaluation of antiviral agents and vaccine candidates. In this review, we discuss the current state of knowledge of mouse models used in PCV2 research that has been performed to date, highlighting their strengths and limitations, as well as prospects for future PCV2 studies.
摘要
猪圆环病毒2型（PCV2）被认为是猪圆环病毒病和猪圆环病毒相关疾病（PCVD/PCVAD）的主要病原体。然而，PCVD/PCVAD的确切发病机制目前尚不清楚。PCV2小鼠模型是有价值的实验工具，可阐明感染的发病机制，并有助于评估抗病毒药物和候选疫苗。在本综述中，我们讨论了迄今为止在PCV2研究中使用的小鼠模型的当前知识状态，强调了它们的优势和局限性，以及未来PCV2研究的前景。
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