Kimura M, Koida T, Sugihara S
Gan To Kagaku Ryoho. 1986 Jul;13(7):2389-92.
The correlation between intralesional 5-FU concentrations and the extent of antitumor effect with particular attention to histopathology was assessed in 30 patients with breast cancer. Therapy consisted of either UFT or FT-207 given preoperatively. Although the UFT-treated group showed a significantly higher intratumoral concentration of 5-FU, there was no intergroup difference in 5-FU levels in normal tissue. In addition, this greater concentration of intratumoral drug had no significant effect on therapeutic response; for both UFT and FT-207 treated groups, the histologic interpretation was rated as grade IIa. Regardless of which drug was used, when tumors were stratified according to histologic type, papillotubular carcinomas revealed the greatest tissue 5-FU levels. However the greatest histologic antitumoral responses were seen in scirrhous carcinomas; hence no correlation was seen here either. The results suggest that attainment of a high intratumoral 5-FU concentration is not reflected in a better histologic tumor response in patients receiving the above drug regimens.
在30例乳腺癌患者中评估了瘤内5-氟尿嘧啶（5-FU）浓度与抗肿瘤效果程度之间的相关性，并特别关注组织病理学。治疗方法为术前给予优福定（UFT）或替加氟（FT-207）。尽管优福定治疗组的肿瘤内5-FU浓度显著更高，但正常组织中的5-FU水平在组间并无差异。此外，肿瘤内药物的这种较高浓度对治疗反应并无显著影响；优福定和替加氟治疗组的组织学判读均为IIa级。无论使用哪种药物，根据组织学类型对肿瘤进行分层时，乳头管状癌的组织5-FU水平最高。然而，在硬癌中观察到最大的组织学抗肿瘤反应；因此这里也未发现相关性。结果表明，在接受上述药物治疗方案的患者中，肿瘤内5-FU浓度较高并不反映在更好的组织学肿瘤反应中。
