Koida T, Kimura M
Gan To Kagaku Ryoho. 1985 May;12(5):1147-51.
In 16 patients with breast cancer who were administered UFT or FT-207 (UFT: 9 cases, FT-207: 7 cases) for a were prior to surgery, we studied the concentrations of 5-FU in the blood and tumor tissues, and in normal and metastatic lymph nodes sampled during surgery. As a result, a high level of 5-FU was found in tumors, especially in metastatic lymph nodes, in the patients who were administered UFT. On the other hand, no significant difference was found between the 5-FU levels of blood in UFT- and FT-treated patients. These facts suggest that UFT can be expected to increase antitumor activity without side effects, especially in cases of metastatic lymph nodes.
对16例术前接受优福定（UFT）或替加氟（FT - 207）（UFT：9例，FT - 207：7例）治疗的乳腺癌患者，我们研究了手术期间采集的血液、肿瘤组织以及正常和转移淋巴结中5 - 氟尿嘧啶（5 - FU）的浓度。结果发现，接受UFT治疗的患者肿瘤中，尤其是转移淋巴结中，5 - FU水平较高。另一方面，UFT治疗组和FT治疗组患者血液中的5 - FU水平无显著差异。这些事实表明，优福定有望在无副作用的情况下增强抗肿瘤活性，尤其是在转移淋巴结的情况下。
