Sobrinho-Simões M, Damjanov I
Arch Pathol Lab Med. 1986 Aug;110(8):722-9.
The lectin-binding properties of human follicular and papillary carcinoma were studied histochemically and compared with lectin binding to normal or goitrous thyroid tissue. Well-differentiated minimally invasive follicular carcinoma showed a lectin-binding pattern essentially identical to those of the normal thyroid gland and benign adenomatous lesions. Overtly invasive follicular carcinoma showed focal reactivity with some lectins that were nonreactive with normal follicular thyroid cells (Solanum tuberosum and soybean in three of three cases; Ulex europaeus in two of three cases; and Dolichos biflorus, Laburnum alpinum, and peanut in one of three cases). In papillary carcinomas, the cells lining the papillary structures reacted focally with some lectins that did not bind to normal thyroid cells (S tuberosum and U europeaus in seven of seven cases; Helix pomatia, Helix aspersa, and soybean in four of seven cases; and peanut, Griffonia simplicifolia, D biflorus, and Vicia villosa in one of seven cases). All these lectins, as well as those reacting with normal thyroid cells, reacted more strongly with cells of papillary structures than with those forming solid nests and follicles. Despite these lectin-defined differences in the composition of glycoconjugates of benign and malignant thyroid cells, the inconsistent and focal nature of the changes precludes the use of lectins in diagnostic histopathology.
对人滤泡状癌和乳头状癌的凝集素结合特性进行了组织化学研究，并与凝集素与正常或甲状腺肿组织的结合情况进行了比较。高分化的微侵袭性滤泡状癌显示出与正常甲状腺和良性腺瘤性病变基本相同的凝集素结合模式。明显侵袭性滤泡状癌对一些凝集素表现出局灶性反应，而这些凝集素与正常滤泡状甲状腺细胞无反应（3例中有3例对马铃薯和大豆凝集素反应；3例中有2例对欧洲荆豆凝集素反应；3例中有1例对双花扁豆、高山金链花和花生凝集素反应）。在乳头状癌中，乳头状结构内衬的细胞对一些不与正常甲状腺细胞结合的凝集素表现出局灶性反应（7例中有7例对马铃薯和欧洲荆豆凝集素反应；7例中有4例对苹果螺、欧洲褐螺和大豆凝集素反应；7例中有1例对花生、西非单叶豆、双花扁豆和绒毛野豌豆凝集素反应）。所有这些凝集素，以及那些与正常甲状腺细胞反应的凝集素，对乳头状结构的细胞反应比对形成实性巢和滤泡的细胞反应更强。尽管在良性和恶性甲状腺细胞的糖缀合物组成上存在这些凝集素定义的差异，但这些变化的不一致性和局灶性使得凝集素在诊断组织病理学中无法使用。
