Department of Biological Science and Technology , China Medical University , No. 91 Hsueh-Shih Road , Taichung , 40402 , Taiwan.
Department of General Surgery , Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation , Taichung , 42743 , Taiwan.
J Nat Prod. 2019 Apr 26;82(4):1002-1008. doi: 10.1021/acs.jnatprod.9b00145. Epub 2019 Mar 20.
Imperatorin is one of the furanocoumarin derivatives and exists in many medicinal herbs with anticancer, antiviral, antibacterial, and antihypertensive activities. In this study, we examined the anti-inflammatory effects of imperatorin on inflammation-associated lung diseases. Imperatorin reduced iNOS and COX-2 expression and also IL-6 and TNFα production enhanced by zymosan. Imperatorin also inhibited the signaling pathways of JAK/STAT and NF-κB. Moreover, in vivo study also revealed that zymosan-induced immune cell infiltration, pulmonary fibrosis, and edema were relieved by imperatorin in mice. We found that imperatorin exerts anti-inflammatory effects that are associated with amelioration of lung inflammation, edema, and rapid fibrosis. Studies on alveolar macrophages also reveal that imperatorin reduced the production of pro-inflammatory mediators and cytokines and inhibited pro-inflammatory JAK1/STAT3 and NF-κB signaling pathways. These results indicate that imperatorin may be a potential anti-inflammatory agent for inflammatory-associated lung diseases.
欧前胡素是呋喃香豆素衍生物之一，存在于许多具有抗癌、抗病毒、抗菌和降压作用的草药中。在这项研究中，我们研究了欧前胡素对炎症相关肺部疾病的抗炎作用。欧前胡素降低了由酵母聚糖增强的诱导型一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）的表达，以及白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNFα）的产生。欧前胡素还抑制了 JAK/STAT 和 NF-κB 信号通路。此外，体内研究还表明，在小鼠中，欧前胡素缓解了酵母聚糖诱导的免疫细胞浸润、肺纤维化和水肿。我们发现，欧前胡素发挥抗炎作用，可改善肺部炎症、水肿和快速纤维化。对肺泡巨噬细胞的研究还表明，欧前胡素减少了促炎介质和细胞因子的产生，并抑制了促炎 JAK1/STAT3 和 NF-κB 信号通路。这些结果表明，欧前胡素可能是一种治疗炎症相关肺部疾病的潜在抗炎药物。
