硫胺素的生物合成。真核生物中嘧啶部分C-5、C-6和羟甲基碳原子的前体。
Biosynthesis of thiamin. Precursor of C-5, C-6, and hydroxymethyl carbon atoms of the pyrimidine moiety in a eucaryote.
作者信息
Tazuya K, Yamamoto M, Hayashiji M, Yamada K, Kumaoka H
出版信息
Biochem Int. 1986 May;12(5):661-8.
PMID:3089223
Abstract
We studied the incorporation of radioactive glucose into the pyrimidine moiety of thiamin in the eucaryote Candida utilis. Three carbons of glucose were incorporated into the pyrimidine, and the C-2 of glucose into the C-6 of the pyrimidine. We concluded that the C-5, -6, and hydroxymethyl carbon atoms of the pyrimidine in this eucaryote originate from the C-2, -3 and -4 of glucose via ribose.
摘要
我们研究了放射性葡萄糖在真核生物产朊假丝酵母中掺入硫胺嘧啶部分的情况。葡萄糖的三个碳原子掺入到嘧啶中，葡萄糖的C-2掺入到嘧啶的C-6中。我们得出结论，这种真核生物中嘧啶的C-5、-6和羟甲基碳原子经由核糖源自葡萄糖的C-2、-3和-4。
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