University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Department of Dermatology, University of California-Irvine, Irvine, CA, USA.
Int J Dermatol. 2019 Dec;58(12):1371-1376. doi: 10.1111/ijd.14404. Epub 2019 Mar 20.
Atopic dermatitis (AD) is a chronic, inflammatory skin disorder characterized by disruption of epidermal barrier function and aberrant immune response to antigens. Current therapies focus on symptom management by restoring epidermal barrier function with emollients and reducing inflammation. Given the prevalence of "steroid phobia" and reported dissatisfaction with first-line therapies, oral vitamins and supplements have been proposed as promising complementary and alternative therapies. The purpose of this systematic review is to evaluate the evidence for various oral vitamins and supplements for the treatment of AD. A literature search was performed in February 2018 in MEDLINE, EMBASE, and Cochrane databases. Included studies were clinical trials and meta-analyses on the oral supplementation of vitamins and supplements for the treatment or prevention of AD. The search identified over 300 articles, of which 37 were included for review. Supplementation with vitamins E and D have the most robust evidence for AD symptom management. Probiotics may play a role in the prevention of infantile AD. Fatty acids such as docosahexaenoic acid, sea buckthorn oil, and hempseed oil also have preliminary evidence for use as supplements to decrease AD severity, but randomized controlled trials are needed. Vitamins and supplements may have a role in the management of AD, however, many of the studies reviewed are limited by small sample size. More studies are needed to better inform medical providers and patients about the role of these treatments in the management of AD.
特应性皮炎（AD）是一种慢性炎症性皮肤病，其特征是表皮屏障功能障碍和对抗原的异常免疫反应。目前的治疗方法侧重于通过使用保湿剂恢复表皮屏障功能和减少炎症来控制症状。鉴于“类固醇恐惧症”的流行和对一线治疗方法的不满，口服维生素和补充剂已被提议作为有前途的补充和替代疗法。本系统评价的目的是评估各种口服维生素和补充剂治疗 AD 的证据。2018 年 2 月在 MEDLINE、EMBASE 和 Cochrane 数据库中进行了文献检索。纳入的研究为关于口服补充维生素和补充剂治疗或预防 AD 的临床试验和荟萃分析。该检索确定了 300 多篇文章，其中 37 篇被纳入审查。补充维生素 E 和 D 对 AD 症状管理有最有力的证据。益生菌可能在预防婴儿特应性皮炎方面发挥作用。二十二碳六烯酸、沙棘油和大麻籽油等脂肪酸也有初步证据可作为减轻 AD 严重程度的补充剂，但需要进行随机对照试验。维生素和补充剂可能在 AD 的管理中发挥作用，然而，许多已审查的研究受到样本量小的限制。需要更多的研究来更好地为医疗保健提供者和患者提供有关这些治疗方法在 AD 管理中的作用的信息。
