Stel H V, Oudejans C B, Veerman E C, Meijer C J
Br J Haematol. 1986 Jul;63(3):565-69. doi: 10.1111/j.1365-2141.1986.tb07534.x.
DNA-recombinant studies have established that factor VIII-mRNA is present in liver and placental tissue. In a previous immunohistological study using monoclonal antibodies we have localized factor VIII in liver sinusoidal endothelial cells. In this paper we demonstrate that also the endothelial cells lining the fetal vessels in human placenta contain factor VIII. Based on the combined results of the present study and a previous study we favour the concept that factor VIII is synthesized in placental endothelial cells.
DNA重组研究已证实，肝脏和胎盘组织中存在凝血因子VIII - mRNA。在先前一项使用单克隆抗体的免疫组织学研究中，我们已将凝血因子VIII定位于肝血窦内皮细胞。在本文中，我们证明人胎盘胎儿血管内衬的内皮细胞也含有凝血因子VIII。基于本研究及先前一项研究的综合结果，我们倾向于认为凝血因子VIII是由胎盘内皮细胞合成的这一观点。
